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1
Spontaneous release of the Leu-2 (T8) molecule from human T cells.人T细胞中Leu-2（T8）分子的自发释放。
J Exp Med. 1983 Sep 1;158(3):752-66. doi: 10.1084/jem.158.3.752.
2
Soluble interleukin 2 receptors are released from activated human lymphoid cells in vitro.可溶性白细胞介素2受体在体外从活化的人淋巴细胞中释放出来。
J Immunol. 1985 Nov;135(5):3172-7.
3
Cytoimmunological monitoring in acute rejection and viral, bacterial or fungal infection following transplantation.移植后急性排斥反应以及病毒、细菌或真菌感染中的细胞免疫监测。
J Heart Transplant. 1985 Jul-Aug;4(4):390-4.
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Enumeration of transferrin-receptor-expressing lymphocytes as a potential marker for rejection in human cardiac transplant recipients.
Transplantation. 1986 Dec;42(6):691-4.
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Interleukin 6 (IL-6) in serum and urine of renal transplant recipients.肾移植受者血清和尿液中的白细胞介素6（IL-6）
Clin Exp Immunol. 1988 Feb;71(2):314-9.
6
Lymphocyte subpopulation monitoring in cyclosporine-treated patients following heart transplantation.心脏移植后接受环孢素治疗患者的淋巴细胞亚群监测
Ann Thorac Surg. 1988 Jan;45(1):11-5. doi: 10.1016/s0003-4975(10)62385-5.
7
Soluble interleukin 2 receptors are elevated in patients with AIDS or at risk of developing AIDS.可溶性白细胞介素2受体在艾滋病患者或有患艾滋病风险的患者中升高。
Clin Immunol Immunopathol. 1987 Dec;45(3):440-6. doi: 10.1016/0090-1229(87)90095-x.
8
Soluble interleukin-2 receptors in the sera of patients with hairy cell leukemia: relationship with the effect of recombinant alpha-interferon therapy on clinical parameters and natural killer in vitro activity.毛细胞白血病患者血清中的可溶性白细胞介素-2受体：与重组α-干扰素治疗对临床参数及体外自然杀伤活性的影响的关系。
Blood. 1987 Nov;70(5):1530-5.
9
Soluble interleukin-2 receptor levels in patients with undifferentiated and lymphoblastic lymphomas: correlation with survival.未分化和淋巴细胞性淋巴瘤患者可溶性白细胞介素-2受体水平：与生存的相关性
J Clin Oncol. 1987 Aug;5(8):1262-74. doi: 10.1200/JCO.1987.5.8.1262.
10
High serum interleukin-2 receptor levels are related to advanced disease and a poor outcome in childhood non-Hodgkin's lymphoma.
Blood. 1987 Sep;70(3):624-8.

心脏移植术后患者血清中的可溶性CD8和CD25

Soluble CD8 and CD25 in serum of patients after heart transplantation.

作者信息

Wijngaard P L, Van der Meulen A, Gmelig Meyling F H, De Jonge N, Schuurman H J

机构信息

Heart Transplantation Centre Utrecht/Groningen, Department of Immunology, The Netherlands.

出版信息

Clin Exp Immunol. 1994 Sep;97(3):505-9. doi: 10.1111/j.1365-2249.1994.tb06117.x.

DOI:10.1111/j.1365-2249.1994.tb06117.x
PMID:8082307
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1534859/
Abstract

To evaluate the diagnostic value of serum cytokine levels and cytokine receptor levels in the diagnosis of acute rejection after heart transplantation, we measured soluble CD8 and soluble CD25 in the serum of heart transplant recipients. The results were compared with endomyocardial biopsy (EMB) histopathology, lymphocyte activation by morphologic inspection of peripheral blood cells (cytoimmunologic monitoring), clinically manifested infections, and the maintenance immunosuppressive therapy. Significantly increased levels were observed in cases of lymphocyte activation in cytoimmunologic monitoring indicative of either rejection or infection. In clinically documented cytomegalovirus (CMV), bacterial, and Pneumocystis carinii infections, increased levels of soluble CD25 were observed. Soluble CD8 was only increased in a single case of P. carinii infection. A statistically significant correlation was calculated between the levels of soluble CD8 and whole blood cyclosporin A level. Considering chemotherapy, the levels of soluble CD8 showed an inverse correlation with the daily dosage of azathioprine. In conclusion, the levels of soluble CD8 and CD25 are associated with lymphocyte activation in peripheral blood, but do not differentiate between lymphocyte activation indicative of rejection or infection. No relationship was observed between levels of soluble CD8 and CD25, and EMB histopathology. Therefore, the assessment of these two cell products has no diagnostic potential for monitoring acute rejection after heart transplantation.

摘要

为评估血清细胞因子水平和细胞因子受体水平在心脏移植术后急性排斥反应诊断中的价值，我们检测了心脏移植受者血清中的可溶性CD8和可溶性CD25。将结果与心内膜心肌活检（EMB）组织病理学、通过外周血细胞形态学检查进行的淋巴细胞活化（细胞免疫监测）、临床表现出的感染以及维持性免疫抑制治疗进行比较。在细胞免疫监测中，提示排斥或感染的淋巴细胞活化病例中观察到水平显著升高。在临床记录的巨细胞病毒（CMV）、细菌和卡氏肺孢子虫感染中，观察到可溶性CD25水平升高。可溶性CD8仅在1例卡氏肺孢子虫感染中升高。计算出可溶性CD8水平与全血环孢素A水平之间存在统计学显著相关性。考虑化疗因素，可溶性CD8水平与硫唑嘌呤每日剂量呈负相关。总之，可溶性CD8和CD25水平与外周血淋巴细胞活化相关，但无法区分提示排斥或感染的淋巴细胞活化。未观察到可溶性CD8和CD25水平与EMB组织病理学之间存在关联。因此，对这两种细胞产物的评估在监测心脏移植术后急性排斥反应方面没有诊断潜力。