Liedman Ragner, Hansson Stefan Rocco, Igidbashian Sarah, Akerlund Mats
Department of Obstetrics and Gynecology, University of Lund, Lund, Sweden.
Gynecol Endocrinol. 2009 Mar;25(3):188-93. doi: 10.1080/09513590802573213.
The hormonal system for induction of term and preterm labour is not fully understood. Therefore, we investigated myometrial gene expressions for neurohypophyseal hormones and their receptors, prostaglandin F(2alpha) and ovarian steroid receptors in women delivered by Caesarean section. Myometrial tissue for real time PCR was collected from 39 women delivered at term before and after the onset of labour and preterm. Women delivered electively at term had significantly higher oxytocin receptor mRNA expressions (2.52 +/- 0.37 oxytocin receptor/actin; median +/- SEM) than those delivered with ongoing labour at term (1.01 +/- 0.34; p = 0.015) and those at preterm (1.08 +/- 0.25; p = 0.004). Sub-analyses revealed that the difference at term pregnancies solely was related to patients receiving oxytocin during labour (p = 0.007). These patients had higher oxytocin peptide mRNA levels than those without labour at term (p = 0.009). PGF(2alpha) receptor mRNA concentrations were 27.80 +/- 3.55, 11.46 +/- 2.87 and 19.54 +/- 5.52 PGF receptor/actin, respectively, for the groups. Women without labour at term had higher concentration than those with labour (p = 0.005). Our results suggest that oxytocin, its receptor and the PGF(2alpha) receptor are involved in the regulation of labour through a paracrine mechanism.
诱导足月和早产的激素系统尚未完全明确。因此，我们研究了剖宫产分娩女性子宫肌层中神经垂体激素及其受体、前列腺素F（2α）和卵巢甾体受体的基因表达。通过实时聚合酶链反应收集了39例足月分娩、临产和早产女性的子宫肌层组织。择期足月分娩的女性，其催产素受体mRNA表达水平（2.52±0.37催产素受体/肌动蛋白；中位数±标准误）显著高于足月临产（1.01±0.34；p = 0.015）和早产（1.08±0.25；p = 0.004）的女性。亚组分析显示，仅足月妊娠时的差异与分娩期间接受催产素的患者有关（p = 0.007）。这些患者的催产素肽mRNA水平高于足月未临产患者（p = 0.009）。三组的前列腺素F（2α）受体mRNA浓度分别为27.80±3.55、11.46±2.87和19.54±5.52前列腺素受体/肌动蛋白。足月未临产女性的浓度高于临产女性（p = 0.005）。我们的结果表明，催产素及其受体以及前列腺素F（2α）受体通过旁分泌机制参与分娩的调节。
