Paradowska Joanna, Stodulski Maciej, Mlynarski Jacek
Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland.
Angew Chem Int Ed Engl. 2009;48(24):4288-97. doi: 10.1002/anie.200802038.
Asymmetric organometallic and organocatalytic processes in aqueous systems are currently of great interest. A few years ago, only a few practitioners studied the subject; now organic reactions in water have become one of the most exciting research areas. The quest to identify water-compatible catalysts has evoked an intense search for new possibilities. Following nature's lead, the application of amino acids as sources of chiral information seems particularly promising for aqueous systems. Herein we provide an overview of very recent advances in the area of asymmetric catalysis in water with amino acids and their derivatives as effective catalysts or essential components of catalysts.
目前，水相体系中的不对称有机金属和有机催化过程备受关注。几年前，只有少数从业者研究该领域；如今，水中的有机反应已成为最令人兴奋的研究领域之一。寻找与水兼容的催化剂引发了对新可能性的强烈探索。以自然为引领，将氨基酸用作手性信息源在水相体系中似乎特别有前景。在此，我们概述了以氨基酸及其衍生物作为有效催化剂或催化剂的重要组分，在水相不对称催化领域的最新进展。
