Ichihara Atsuhiro, Ito Hiroshi
Endocrinology and Anti-Aging Medicine, Department of Internal Medicine, Keio University School of Medicine.
Nihon Rinsho. 2009 Apr;67(4):675-80.
Discovery of (pro)renin receptor elucidated that prorenin is not only an inactive precursor of renin but also an endocrine hormone. The binding of prorenin to the (pro) renin receptor triggers two major pathways: the angiotensin II-dependent pathway as a result of nonproteolytic activation of prorenin, and the angiotensin II-independent, (pro)renin-receptor-dependent intracellular pathways. These two pathways of (pro)renin receptor significantly contribute to the development and progression of end organ damage in diabetes and hypertension. However, since renin is still active in the absence of the (pro)renin receptor, the contribution of (pro)renin receptor to the pathogenesis is reduced under conditions with high renin levels. Thus, assessment of the ratio of renin to prorenin is needed to evaluate the significance of (pro)renin receptor.
（前体）肾素受体的发现阐明了肾素原不仅是肾素的无活性前体，也是一种内分泌激素。肾素原与（前体）肾素受体的结合触发两条主要途径：由于肾素原的非蛋白水解激活导致的血管紧张素II依赖性途径，以及血管紧张素II非依赖性、（前体）肾素受体依赖性细胞内途径。（前体）肾素受体的这两条途径显著促进了糖尿病和高血压终末器官损伤的发生和发展。然而，由于在没有（前体）肾素受体的情况下肾素仍具有活性，在肾素水平高的情况下，（前体）肾素受体对发病机制的贡献会降低。因此，需要评估肾素与肾素原的比例来评估（前体）肾素受体的意义。
