Musings on genome medicine: genome wide association studies.
作者信息
Nathan David G, Orkin Stuart H
机构信息
Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA.
出版信息
Genome Med. 2009 Jan 20;1(1):3. doi: 10.1186/gm3.
Abstract
摘要
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Genetic mapping in human disease.人类疾病中的基因定位
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Genome-wide association studies: past, present and future.全基因组关联研究：过去、现在与未来。
Hum Mol Genet. 2008 Oct 15;17(R2):R100-1. doi: 10.1093/hmg/ddn298.
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The horse genome.马的基因组。
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DNA polymorphisms at the BCL11A, HBS1L-MYB, and beta-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease.BCL11A、HBS1L-MYB和β-珠蛋白基因座的DNA多态性与镰状细胞病中的胎儿血红蛋白水平和疼痛危象相关。
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Blood. 2008 Aug 15;112(4):1022-7. doi: 10.1182/blood-2008-01-134247. Epub 2008 Jun 5.
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Common and rare variants in multifactorial susceptibility to common diseases.常见疾病多因素易感性中的常见和罕见变异。
Nat Genet. 2008 Jun;40(6):695-701. doi: 10.1038/ng.f.136.
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A network model to predict the risk of death in sickle cell disease.一种预测镰状细胞病死亡风险的网络模型。
Blood. 2007 Oct 1;110(7):2727-35. doi: 10.1182/blood-2007-04-084921. Epub 2007 Jun 28.
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The International HapMap Project.国际人类基因组单体型图计划
Nature. 2003 Dec 18;426(6968):789-96. doi: 10.1038/nature02168.
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Vast, 15-year effort to decipher genes stirs opposition.为期15年的大规模基因解码工作引发了反对声。
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