Fusar-Poli P, Placentino A, Carletti F, Allen P, Landi P, Abbamonte M, Barale F, Perez J, McGuire P, Politi P L
Department of Psychological Medicine, Institute of Psychiatry, King's College London, United Kingdom.
Neurosci Lett. 2009 Mar 20;452(3):262-7. doi: 10.1016/j.neulet.2009.01.065. Epub 2009 Jan 29.
Recognizing emotion from facial expressions draws on diverse psychological processes implemented in a large array of neural structures. Two major theories of cerebral lateralization of emotional perception have been proposed: (i) the Right-Hemisphere Hypothesis (RHH) and (ii) the Valence-Specific Hypothesis (VSH). To test these lateralization models we conducted a large voxel-based meta-analysis of current functional magnetic resonance imaging (fMRI) studies employing emotional faces paradigms in healthy volunteers. Two independent researchers conducted separate comprehensive PUBMED (1990-May 2008) searches to find all functional magnetic resonance imaging studies using a variant of the emotional faces paradigm in healthy subjects. Out of the 551 originally identified studies, 105 studies met inclusion criteria. The overall database consisted of 1785 brain coordinates which yield an overall sample of 1600 healthy subjects. We found no support for the hypothesis of overall right-lateralization of emotional processing. Conversely, across all emotional conditions the parahippocampal gyrus and amygdala, fusiform gyrus, lingual gyrus, precuneus, inferior and middle occipital gyrus, posterior cingulated, middle temporal gyrus, inferior frontal and superior frontal gyri were activated bilaterally (p=0.001). There was a valence-specific lateralization of brain response during negative emotions processing in the left amygdala (p=0.001). Significant interactions between the approach and avoidance dimensions and prefrontal response were observed (p=0.001).
从面部表情识别情绪依赖于大量神经结构中实现的多种心理过程。关于情绪感知的大脑半球侧化，已经提出了两种主要理论：（i）右半球假说（RHH）和（ii）效价特异性假说（VSH）。为了检验这些侧化模型，我们对当前在健康志愿者中采用情绪面孔范式的功能磁共振成像（fMRI）研究进行了一项基于体素的大型元分析。两名独立研究人员分别在PUBMED（1990年 - 2008年5月）上进行了全面搜索，以查找所有在健康受试者中使用情绪面孔范式变体的功能磁共振成像研究。在最初确定的551项研究中，有105项研究符合纳入标准。整个数据库由1785个脑坐标组成，产生了1600名健康受试者的总体样本。我们没有找到支持情绪加工总体右侧化假说的证据。相反，在所有情绪条件下，双侧海马旁回、杏仁核、梭状回、舌回、楔前叶、枕下回和枕中回、后扣带回、颞中回、额下回和额上回均被激活（p = 0.001）。在负性情绪加工过程中，左侧杏仁核存在效价特异性的脑反应侧化（p = 0.001）。观察到趋近和回避维度与前额叶反应之间存在显著交互作用（p = 0.001）。
