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1
Whither recombinant human leptin treatment for HIV-associated lipoatrophy and the metabolic syndrome?重组人瘦素治疗HIV相关脂肪萎缩和代谢综合征的前景如何？
J Clin Endocrinol Metab. 2009 Apr;94(4):1089-91. doi: 10.1210/jc.2009-0340.
2
The effects of recombinant human leptin on visceral fat, dyslipidemia, and insulin resistance in patients with human immunodeficiency virus-associated lipoatrophy and hypoleptinemia.重组人瘦素对人类免疫缺陷病毒相关脂肪萎缩和低瘦素血症患者内脏脂肪、血脂异常及胰岛素抵抗的影响
J Clin Endocrinol Metab. 2009 Apr;94(4):1137-44. doi: 10.1210/jc.2008-1588. Epub 2009 Jan 27.
3
Recombinant methionyl human leptin therapy in replacement doses improves insulin resistance and metabolic profile in patients with lipoatrophy and metabolic syndrome induced by the highly active antiretroviral therapy.以替代剂量进行的重组甲硫氨酰人瘦素治疗可改善由高效抗逆转录病毒疗法引起的脂肪萎缩和代谢综合征患者的胰岛素抵抗及代谢状况。
J Clin Endocrinol Metab. 2006 Jul;91(7):2605-11. doi: 10.1210/jc.2005-1545. Epub 2006 Apr 24.
4
W(h)ither metreleptin for lipodystrophy and the metabolic syndrome?治疗脂肪营养不良和代谢综合征的美曲普明何去何从？
Endocr Pract. 2010 Mar-Apr;16(2):162-6. doi: 10.4158/EP10038.ED.
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Efficacy of leptin therapy in the different forms of human lipodystrophy.瘦素治疗不同类型人类脂肪营养不良的疗效。
Diabetologia. 2010 Jan;53(1):27-35. doi: 10.1007/s00125-009-1502-9. Epub 2009 Sep 2.
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Leptin reverses nonalcoholic steatohepatitis in patients with severe lipodystrophy.瘦素可逆转重度脂肪营养不良患者的非酒精性脂肪性肝炎。
Hepatology. 2005 Apr;41(4):753-60. doi: 10.1002/hep.20672.
7
The long-term effect of recombinant methionyl human leptin therapy on hyperandrogenism and menstrual function in female and pituitary function in male and female hypoleptinemic lipodystrophic patients.重组甲硫氨酰人瘦素治疗对女性低脂血症性脂肪营养不良患者高雄激素血症和月经功能以及男性和女性垂体功能的长期影响。
Metabolism. 2005 Feb;54(2):255-63. doi: 10.1016/j.metabol.2004.08.021.
8
Leptin and appetite control in lipodystrophy.脂肪营养不良中的瘦素与食欲控制
J Clin Endocrinol Metab. 2004 Sep;89(9):4254-7. doi: 10.1210/jc.2004-1232.
9
Effect of leptin replacement on pituitary hormone regulation in patients with severe lipodystrophy.瘦素替代疗法对严重脂肪营养不良患者垂体激素调节的影响。
J Clin Endocrinol Metab. 2002 Jul;87(7):3110-7. doi: 10.1210/jcem.87.7.8591.
10
The clinical efficacy of the adipocyte-derived hormone leptin in metabolic dysfunction.脂肪细胞衍生激素瘦素在代谢功能障碍中的临床疗效。
Arch Physiol Biochem. 2006 Apr;112(2):114-8. doi: 10.1080/13813450600736117.

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1
Leptin in relation to the lipodystrophy-associated metabolic syndrome.瘦素与脂肪营养不良相关代谢综合征的关系。
Diabetes Metab J. 2012 Jun;36(3):181-9. doi: 10.4093/dmj.2012.36.3.181. Epub 2012 Jun 14.
2
Leptin as a modulator of neuroendocrine function in humans.瘦素作为人类神经内分泌功能的调节剂。
Yonsei Med J. 2012 Jul 1;53(4):671-9. doi: 10.3349/ymj.2012.53.4.671.
3
Repositioning leptin as a therapy for Alzheimer's disease.将瘦素重新定位为治疗阿尔茨海默病的方法。
Therapy. 2011 Sep;8(5):481-490. doi: 10.2217/thy.11.57.
4
Leptin in human physiology and pathophysiology.瘦素在人类生理学和病理生理学中的作用。
Am J Physiol Endocrinol Metab. 2011 Oct;301(4):E567-84. doi: 10.1152/ajpendo.00315.2011. Epub 2011 Jul 26.
5
Lipodystrophy: pathophysiology and advances in treatment.脂肪营养不良：病理生理学和治疗进展。
Nat Rev Endocrinol. 2011 Mar;7(3):137-50. doi: 10.1038/nrendo.2010.199. Epub 2010 Nov 16.
6
Body fat redistribution and metabolic abnormalities in HIV-infected patients on highly active antiretroviral therapy: novel insights into pathophysiology and emerging opportunities for treatment.接受高效抗逆转录病毒治疗的HIV感染患者的体脂重新分布和代谢异常：对病理生理学的新见解及新出现的治疗机会
Metabolism. 2011 Jun;60(6):749-53. doi: 10.1016/j.metabol.2010.09.011. Epub 2010 Oct 20.
7
Longitudinal assessment of metabolic abnormalities in adolescents and young adults with HIV-infection acquired perinatally or in early childhood.对经母婴垂直传播或婴幼儿期感染 HIV 的青少年和青年人群代谢异常的纵向评估。
Metabolism. 2011 Jun;60(6):874-80. doi: 10.1016/j.metabol.2010.08.007. Epub 2010 Oct 13.
8
Leptin in human physiology and therapeutics.瘦素在人类生理学和治疗学中的作用。
Front Neuroendocrinol. 2010 Jul;31(3):377-93. doi: 10.1016/j.yfrne.2010.06.002. Epub 2010 Jun 17.
9
Narrative review: the role of leptin in human physiology: emerging clinical applications.叙述性评论：瘦素在人类生理学中的作用：新兴的临床应用。
Ann Intern Med. 2010 Jan 19;152(2):93-100. doi: 10.7326/0003-4819-152-2-201001190-00008.
10
Leptin deficiency: clinical implications and opportunities for therapeutic interventions.瘦素缺乏：临床意义及治疗干预机会。
J Investig Med. 2009 Oct;57(7):784-8. doi: 10.2310/JIM.0b013e3181b9163d.

本文引用的文献

1
Leptin in humans: lessons from translational research.人类的瘦素：转化研究的经验教训。
Am J Clin Nutr. 2009 Mar;89(3):991S-997S. doi: 10.3945/ajcn.2008.26788E. Epub 2009 Jan 28.
2
The effects of recombinant human leptin on visceral fat, dyslipidemia, and insulin resistance in patients with human immunodeficiency virus-associated lipoatrophy and hypoleptinemia.重组人瘦素对人类免疫缺陷病毒相关脂肪萎缩和低瘦素血症患者内脏脂肪、血脂异常及胰岛素抵抗的影响
J Clin Endocrinol Metab. 2009 Apr;94(4):1137-44. doi: 10.1210/jc.2008-1588. Epub 2009 Jan 27.
3
r-metHuLeptin improves highly active antiretroviral therapy-induced lipoatrophy and the metabolic syndrome, but not through altering circulating IGF and IGF-binding protein levels: observational and interventional studies in humans.重组甲硫氨酸人瘦素可改善高效抗逆转录病毒治疗引起的脂肪萎缩和代谢综合征，但并非通过改变循环中的胰岛素样生长因子（IGF）及其结合蛋白水平：人体观察性和干预性研究
Eur J Endocrinol. 2009 Feb;160(2):173-6. doi: 10.1530/EJE-08-0597. Epub 2008 Nov 24.
4
Deconvolution of insulin secretion, insulin hepatic extraction post-hepatic delivery rates and sensitivity during 24-hour standardized meals: time course of glucose homeostasis in leptin replacement treatment.24小时标准化进餐期间胰岛素分泌、肝后胰岛素递送率及肝脏提取率和敏感性的反卷积分析：瘦素替代治疗中葡萄糖稳态的时间进程
Horm Metab Res. 2009 Feb;41(2):142-51. doi: 10.1055/s-0028-1082048. Epub 2008 Aug 22.
5
Low-dose physiological growth hormone in patients with HIV and abdominal fat accumulation: a randomized controlled trial.低剂量生理性生长激素用于HIV感染及腹部脂肪堆积患者：一项随机对照试验
JAMA. 2008 Aug 6;300(5):509-19. doi: 10.1001/jama.300.5.509.
6
Metabolic effects of a growth hormone-releasing factor in patients with HIV.生长激素释放因子对HIV患者的代谢影响。
N Engl J Med. 2007 Dec 6;357(23):2359-70. doi: 10.1056/NEJMoa072375.
7
Efficacy and safety of leptin-replacement therapy and possible mechanisms of leptin actions in patients with generalized lipodystrophy.瘦素替代疗法在泛发性脂肪营养不良患者中的疗效与安全性以及瘦素作用的可能机制
J Clin Endocrinol Metab. 2007 Feb;92(2):532-41. doi: 10.1210/jc.2006-1546. Epub 2006 Nov 21.
8
Recombinant methionyl human leptin therapy in replacement doses improves insulin resistance and metabolic profile in patients with lipoatrophy and metabolic syndrome induced by the highly active antiretroviral therapy.以替代剂量进行的重组甲硫氨酰人瘦素治疗可改善由高效抗逆转录病毒疗法引起的脂肪萎缩和代谢综合征患者的胰岛素抵抗及代谢状况。
J Clin Endocrinol Metab. 2006 Jul;91(7):2605-11. doi: 10.1210/jc.2005-1545. Epub 2006 Apr 24.
9
Long-term efficacy of leptin replacement in patients with generalized lipodystrophy.瘦素替代疗法对泛发性脂肪营养不良患者的长期疗效。
Diabetes. 2005 Jul;54(7):1994-2002. doi: 10.2337/diabetes.54.7.1994.
10
Leptin reverses nonalcoholic steatohepatitis in patients with severe lipodystrophy.瘦素可逆转重度脂肪营养不良患者的非酒精性脂肪性肝炎。
Hepatology. 2005 Apr;41(4):753-60. doi: 10.1002/hep.20672.

Whither recombinant human leptin treatment for HIV-associated lipoatrophy and the metabolic syndrome?

作者信息

Mantzoros Christos S

出版信息

J Clin Endocrinol Metab. 2009 Apr;94(4):1089-91. doi: 10.1210/jc.2009-0340.

DOI:10.1210/jc.2009-0340
PMID:19349474
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2730231/
Abstract
摘要