Joó József Gábor, Beke Artúr, Berkes Eniko, Papp Zoltán, Rigó János, Papp Csaba
First Department of Obstetrics and Gynaecology, Faculty of General Medicine, Semmelweis University, Budapest, Hungary.
Fetal Diagn Ther. 2009;25(2):186-91. doi: 10.1159/000210832. Epub 2009 Apr 7.
We aimed to analyze, based upon autopsy, the main characteristics of miscarriages in the second trimester.
We have processed the results of fetopathological investigations of 544 aborted fetuses resulting from 486 second-trimester miscarriages.
Malformation could be identified in 13.05% of all cases. In almost one third of the patients there was a positive history. In the cases having a malformation, expressed dominance of male fetuses could be observed. Among the fetopathologically identified malformations, 49 were isolated. The most common was the single umbilical artery (22.4%). In 1.3% of the cases a chromosome aberration was verified.
Miscarriage in pregnancies complicated by a malformation occurs approximately 3 weeks earlier than in cases without a confirmed malformation. There is practically no difference between affected and unaffected miscarriages as far as the cumulative ratio of positive history is concerned. A single umbilical artery alone predisposes to miscarriage, while in association with other malformations it may result from chromosome aberration.
我们旨在通过尸检分析妊娠中期流产的主要特征。
我们对486例妊娠中期流产所产生的544例流产胎儿的胎儿病理学检查结果进行了处理。
在所有病例中，13.05%可发现畸形。近三分之一的患者有阳性病史。在有畸形的病例中，可以观察到男性胎儿占明显优势。在胎儿病理学鉴定出的畸形中，49例为单发。最常见的是单脐动脉（22.4%）。在1.3%的病例中证实存在染色体畸变。
伴有畸形的妊娠流产比未确诊畸形的妊娠流产大约早3周发生。就阳性病史的累积比例而言，受影响和未受影响的流产之间实际上没有差异。单脐动脉本身易导致流产，而与其他畸形相关时可能是由染色体畸变引起的。
