Senok Abiola C, Ismaeel Abdulrahman Y, Al-Qashar Fahad A, Agab Wahid A
Department of Clinical Sciences, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.
Med Princ Pract. 2009;18(3):170-4. doi: 10.1159/000204345. Epub 2009 Apr 6.
To evaluate the pattern of antibiotic prescriptions for paediatric upper respiratory tract infections (URTI) and determine the associated predictors for such antibiotic use in the Kingdom of Bahrain.
From March 2005 to March 2006, demographic data, clinical presentation, investigations and antibiotic prescription for children with URTI (n = 184) at the Bahrain Defence Force Hospital was recorded. To assess the factors which influence physician antibiotic prescription for URTI, a cross-sectional survey of doctors was carried out using a pre-tested questionnaire which was administered to paediatricians, general practitioners and emergency room physicians.
Antibiotics were given to 95 of the 184 (51.6%) patients, mainly children <3 years (40/95). Significant association was demonstrated for antibiotic prescription, age and diagnosis of tonsillitis or acute otitis media (p < 0.05). Amoxicillin (37/95) was the most frequently prescribed antibiotic, followed by beta-lactam/beta-lactamase combination and second-generation cephalosporins. Fever, younger age, sore throat and presence of earache increased the likelihood of antibiotic prescription. Data from the cross-sectional survey of doctors revealed that lack of national guidelines, parental pressure and diagnostic uncertainty contributed to antibiotic overuse.
Antibiotic overuse for the treatment of paediatric URTI remains a problem in our setting. We suggest the development of national guidelines which are integrated with structured continuing medical education courses, public awareness campaigns and the introduction of rapid streptococcal antigen tests in the outpatient clinic.
评估巴林王国儿童上呼吸道感染(URTI)的抗生素处方模式,并确定此类抗生素使用的相关预测因素。
2005年3月至2006年3月期间,记录了巴林国防军医院184例URTI患儿的人口统计学数据、临床表现、检查及抗生素处方情况。为评估影响医生对URTI患儿开具抗生素处方的因素,采用预先测试的问卷对儿科医生、全科医生和急诊室医生进行了横断面调查。
184例患者中有95例(51.6%)接受了抗生素治疗,主要是3岁以下儿童(40/95)。抗生素处方、年龄以及扁桃体炎或急性中耳炎的诊断之间存在显著关联(p<0.05)。阿莫西林(37/95)是最常开具的抗生素,其次是β-内酰胺/β-内酰胺酶联合制剂和第二代头孢菌素。发热、年龄较小、喉咙痛和耳痛增加了开具抗生素处方的可能性。医生横断面调查的数据显示,缺乏国家指南、家长压力和诊断不确定性导致了抗生素的过度使用。
在我们的环境中,抗生素过度用于治疗儿童URTI仍然是一个问题。我们建议制定国家指南,将其与结构化的继续医学教育课程、公众宣传活动以及在门诊引入快速链球菌抗原检测相结合。