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儿童抗生素处方的前瞻性研究。

Prospective study of antibiotic prescribing for children.

作者信息

Pennie R A

机构信息

Department of Pathology, McMaster University Faculty of Health Sciences, Hamilton, Ont.

出版信息

Can Fam Physician. 1998 Sep;44:1850-6.

Abstract

OBJECTIVES

To observe the frequency with which children in outpatient primary care settings are prescribed antibiotics and to investigate why these antibiotics are prescribed. To compare the prescribing behaviour of family doctors, primary care pediatricians, and urgent care physicians and to determine where refinements in management are most needed to reduce the number of antibiotic prescriptions appropriately.

DESIGN

Prospective study using a data entry form with mostly closed-ended questions.

SETTING

Ten primary care offices in urban south-central and eastern Ontario: five family practices, three pediatric practices, and two urgent care centres (UCC).

PARTICIPANTS

Every child younger than 16 years visiting these offices during a 3-week period in February and March 1997.

MAIN OUTCOME MEASURES

Frequency, clinical indications, and nature of the antibiotics prescribed.

RESULTS

There were 4344 observed visits. Of 1706 antibiotic prescriptions, 1481 were for 10 days, and 1577 (92%) were for acute respiratory infections, 920 (53%) specifically for acute otitis media (AOM). Full courses of antibiotics were given immediately (i.e., without test results) to 321 (76%) of 425 children with pharyngitis. Antibiotics were prescribed for 145 (90%) of 163 children with bronchitis. Urgent care physicians were significantly more likely than pediatricians or family physicians to prescribe immediate antibiotics and to disregard guidelines when choosing antibiotics for uncomplicated AOM.

CONCLUSIONS

Three diagnoses accounted for 82% of antibiotic prescriptions: AOM, pharyngitis, and bronchitis. Physicians should be more selective when deciding whether, and for how long, to prescribe antibiotics for those three common conditions. Substantial reductions in antibiotic use will require changes in how physicians manage suspected AOM, the most common indication for antibiotics.

摘要

目的

观察门诊初级保健机构中儿童使用抗生素的频率,并调查使用这些抗生素的原因。比较家庭医生、初级保健儿科医生和紧急护理医生的处方行为,确定在哪些方面最需要改进管理以适当减少抗生素处方数量。

设计

采用主要为封闭式问题的数据录入表进行前瞻性研究。

地点

安大略省中南部和东部城市的十家初级保健机构:五家家庭诊所、三家儿科诊所和两家紧急护理中心(UCC)。

参与者

1997年2月和3月为期3周内到这些机构就诊的所有16岁以下儿童。

主要观察指标

所开抗生素的频率、临床指征和性质。

结果

共观察到4344次就诊。在1706份抗生素处方中,1481份为10天用量,1577份(92%)用于急性呼吸道感染,920份(53%)专门用于急性中耳炎(AOM)。425例咽炎患儿中有321例(76%)在未得到检测结果时就立即给予了全程抗生素治疗。163例支气管炎患儿中有145例(90%)使用了抗生素。与儿科医生或家庭医生相比,紧急护理医生更有可能立即开具抗生素,并且在为无并发症的AOM选择抗生素时无视指南。

结论

三种诊断占抗生素处方的82%:AOM、咽炎和支气管炎。医生在决定是否以及为这三种常见病症开具抗生素多长时间时应更加谨慎。大幅减少抗生素使用将需要改变医生对疑似AOM(抗生素最常见的使用指征)的处理方式。

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