中性粒细胞“三明治”损伤微循环。
Neutrophil sandwiches injure the microcirculation.
作者信息
Looney Mark R, Matthay Michael A
出版信息
Nat Med. 2009 Apr;15(4):364-6. doi: 10.1038/nm0409-364.
Abstract
Experiments in two mouse models of thromboinflammatory disease show how neutrophils stick to red blood cells and platelets—leading to reduced blood flow and damage to the microcirculation. Polarized expression of αβ integrins on neutrophils helps set the process in motion (pages 384−391).
摘要
在两种血栓炎症性疾病小鼠模型中进行的实验表明了中性粒细胞如何黏附于红细胞和血小板，进而导致血流减少和微循环损伤。中性粒细胞上αβ整合素的极化表达有助于启动这一过程（第384 - 391页）。
相似文献
1
Neutrophil sandwiches injure the microcirculation.中性粒细胞“三明治”损伤微循环。
Nat Med. 2009 Apr;15(4):364-6. doi: 10.1038/nm0409-364.
2
Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury.血小板在输血相关急性肺损伤中诱导中性粒细胞胞外陷阱形成。
J Clin Invest. 2012 Jul;122(7):2661-71. doi: 10.1172/JCI61303. Epub 2012 Jun 11.
3
4
Platelet and Erythrocyte Extravasation across Inflamed Corneal Venules Depend on CD18, Neutrophils, and Mast Cell Degranulation.血小板和红细胞从炎性角膜小静脉渗出依赖于 CD18、中性粒细胞和肥大细胞脱颗粒。
Int J Mol Sci. 2021 Jul 8;22(14):7360. doi: 10.3390/ijms22147360.
5
RBC adhesion to cremaster endothelum in mice with abnormal hemoglobin is increased by topical endotoxin.局部内毒素可增加血红蛋白异常小鼠的红细胞与提睾肌内皮的黏附。
Ann N Y Acad Sci. 1998 Jun 30;850:391-3. doi: 10.1111/j.1749-6632.1998.tb10500.x.
6
Adhesion of sickle neutrophils and erythrocytes to fibronectin.镰状中性粒细胞和红细胞与纤连蛋白的黏附
Blood. 1996 Jan 15;87(2):771-80.
7
Heterotypic interactions enabled by polarized neutrophil microdomains mediate thromboinflammatory injury.由极化中性粒细胞微区实现的异型相互作用介导血栓性炎症损伤。
Nat Med. 2009 Apr;15(4):384-91. doi: 10.1038/nm.1939. Epub 2009 Mar 22.
8
Thrombospondin from activated platelets promotes sickle erythrocyte adherence to human microvascular endothelium under physiologic flow: a potential role for platelet activation in sickle cell vaso-occlusion.活化血小板中的血小板反应蛋白在生理血流状态下促进镰状红细胞与人类微血管内皮细胞的黏附：血小板活化在镰状细胞血管阻塞中的潜在作用。
Blood. 1993 Apr 15;81(8):2137-43.
9
Sickle cell vaso-occlusion.镰状细胞血管阻塞
Hematol Oncol Clin North Am. 1991 Jun;5(3):375-98.
10
[Role of neutrophil granulocytes and platelets in the pathology of microcirculation].[中性粒细胞和血小板在微循环病理中的作用]
Cardiologia. 1995 Dec;40(12 Suppl 1):13-6.
引用本文的文献
1
Histone H4 aggravates inflammatory injury through TLR4 in chlorine gas-induced acute respiratory distress syndrome.组蛋白H4通过Toll样受体4加重氯气诱导的急性呼吸窘迫综合征中的炎症损伤。
J Occup Med Toxicol. 2020 Oct 8;15:31. doi: 10.1186/s12995-020-00282-z. eCollection 2020.
2
CRAC channel regulation of innate immune cells in health and disease.CRAC 通道在先天免疫细胞中的调节作用：健康与疾病。
Cell Calcium. 2019 Mar;78:56-65. doi: 10.1016/j.ceca.2019.01.003. Epub 2019 Jan 9.
3
Rheumatoid Arthritis in Sickle-Cell Population: Pathophysiologic Insights, Clinical Evaluation and Management.镰状细胞人群中的类风湿性关节炎：病理生理见解、临床评估与管理
Rheumatology (Sunnyvale). 2017;7(3). doi: 10.4172/2161-1149.1000225. Epub 2017 Sep 12.
4
Prevalence and Clinical Characteristics of Rheumatoid Arthritis in an Inner City Population with Sickle Cell Disease.镰状细胞病城市中心人群中类风湿性关节炎的患病率及临床特征
Rheumatology (Sunnyvale). 2017 Jun;7(2). doi: 10.4172/2329-8731.1000218. Epub 2017 Apr 28.
5
Neutrophil stunning by metoprolol reduces infarct size.美托洛尔使中性粒细胞“失活”，减少梗死面积。
Nat Commun. 2017 Apr 18;8:14780. doi: 10.1038/ncomms14780.
6
Pulmonary endothelial activation caused by extracellular histones contributes to neutrophil activation in acute respiratory distress syndrome.细胞外组蛋白引起的肺内皮细胞激活促成急性呼吸窘迫综合征中的中性粒细胞激活。
Respir Res. 2016 Nov 21;17(1):155. doi: 10.1186/s12931-016-0472-y.
7
Role of the Mycoplasma pneumoniae/Interleukin-8/Neutrophil Axis in the Pathogenesis of Pneumonia.肺炎支原体/白细胞介素-8/中性粒细胞轴在肺炎发病机制中的作用
PLoS One. 2016 Jan 11;11(1):e0146377. doi: 10.1371/journal.pone.0146377. eCollection 2016.
8
Septic shock and chemotherapy-induced cytopenia: effects on microcirculation.脓毒症休克和化疗引起的血细胞减少症：对微循环的影响。
Intensive Care Med. 2012 Aug;38(8):1336-44. doi: 10.1007/s00134-012-2582-4. Epub 2012 May 15.
9
Human mesenchymal stem cells reduce mortality and bacteremia in gram-negative sepsis in mice in part by enhancing the phagocytic activity of blood monocytes.人骨髓间充质干细胞通过增强血单核细胞的吞噬活性，部分降低了革兰氏阴性菌败血症小鼠的死亡率和菌血症。
Am J Physiol Lung Cell Mol Physiol. 2012 May 15;302(10):L1003-13. doi: 10.1152/ajplung.00180.2011. Epub 2012 Mar 16.
10
Fresh and stored red blood cell transfusion equivalently induce subclinical pulmonary gas exchange deficit in normal humans.新鲜和储存的红细胞输血在正常人体中同样引起亚临床的肺气体交换不足。
Anesth Analg. 2012 Mar;114(3):511-9. doi: 10.1213/ANE.0b013e318241fcd5. Epub 2012 Jan 19.
本文引用的文献
1
Heterotypic interactions enabled by polarized neutrophil microdomains mediate thromboinflammatory injury.由极化中性粒细胞微区实现的异型相互作用介导血栓性炎症损伤。
Nat Med. 2009 Apr;15(4):384-91. doi: 10.1038/nm.1939. Epub 2009 Mar 22.
2
Pulmonary complications of sickle cell disease.镰状细胞病的肺部并发症
N Engl J Med. 2008 Nov 20;359(21):2254-65. doi: 10.1056/NEJMra0804411.
3
Amicus or adversary: platelets in lung biology, acute injury, and inflammation.友方还是敌方：血小板在肺生物学、急性损伤及炎症中的作用
Am J Respir Cell Mol Biol. 2009 Feb;40(2):123-34. doi: 10.1165/rcmb.2008-0241TR. Epub 2008 Aug 21.
4
The pathogenesis of transfusion-related acute lung injury (TRALI).输血相关急性肺损伤（TRALI）的发病机制。
Br J Haematol. 2007 Mar;136(6):788-99. doi: 10.1111/j.1365-2141.2007.06492.x.
5
Complete reversal of acid-induced acute lung injury by blocking of platelet-neutrophil aggregation.通过阻断血小板-中性粒细胞聚集完全逆转酸诱导的急性肺损伤。
J Clin Invest. 2006 Dec;116(12):3211-9. doi: 10.1172/JCI29499.
6
Neutrophils and their Fc gamma receptors are essential in a mouse model of transfusion-related acute lung injury.在输血相关急性肺损伤的小鼠模型中，中性粒细胞及其Fcγ受体至关重要。
J Clin Invest. 2006 Jun;116(6):1615-23. doi: 10.1172/JCI27238. Epub 2006 May 18.
7
Transfusion-related acute lung injury: definition and review.输血相关急性肺损伤：定义与综述
Crit Care Med. 2005 Apr;33(4):721-6. doi: 10.1097/01.ccm.0000159849.94750.51.
8
Unique structural features that influence neutrophil emigration into the lung.影响中性粒细胞向肺部迁移的独特结构特征。
Physiol Rev. 2003 Apr;83(2):309-36. doi: 10.1152/physrev.00023.2002.
9
The acute respiratory distress syndrome.急性呼吸窘迫综合征
N Engl J Med. 2000 May 4;342(18):1334-49. doi: 10.1056/NEJM200005043421806.
10
Pathogenesis and treatment of sickle cell disease.镰状细胞病的发病机制与治疗
N Engl J Med. 1997 Sep 11;337(11):762-9. doi: 10.1056/NEJM199709113371107.
Zotero 插件