Isago T, Fujioka K, Traber L D, Herndon D N, Traber D L
Department of Anesthesiology, University of Texas Medical Branch, Galveston.
Crit Care Med. 1991 Nov;19(11):1407-13. doi: 10.1097/00003246-199111000-00018.
We determined derived pulmonary capillary pressure and the longitudinal distribution of pulmonary vascular resistance in chronically instrumented sheep with inhalation injury by using analysis of pressure decay curves after pulmonary artery occlusion.
There was an increase in derived pulmonary capillary pressure and an increase in the lung lymph flow after smoke inhalation. The pulmonary vascular, arterial, and venous resistances increased significantly in the inhalation group. Pulmonary venous resistance increased proportionately more than pulmonary arterial resistance in the inhalation group. The plasma osmotic pressure-derived pulmonary capillary pressure gradient decreased to a greater extent in the inhalation group than in the control group.
The present experiments suggest that the estimates of derived pulmonary capillary pressure can predict filtration pressure better than pulmonary artery occlusion pressure. The derived pulmonary capillary pressure can be measured easily in man with a pulmonary arterial catheter.
我们通过分析肺动脉闭塞后压力衰减曲线，测定了慢性植入仪器的吸入性损伤绵羊的肺动脉毛细血管压力和肺血管阻力的纵向分布。
烟雾吸入后，肺动脉毛细血管压力升高，肺淋巴流量增加。吸入组的肺血管、动脉和静脉阻力显著增加。吸入组中肺静脉阻力的增加幅度大于肺动脉阻力。与对照组相比，吸入组中血浆渗透压衍生的肺动脉毛细血管压力梯度下降幅度更大。
本实验表明，肺动脉毛细血管压力的估算值比肺动脉闭塞压能更好地预测滤过压。通过肺动脉导管可在人体中轻松测量肺动脉毛细血管压力。
