利用生物技术在药物研发方面的专业知识来应对被忽视的疾病。 - Suppr

Suppr

超能文献

Leveraging biotech's drug discovery expertise for neglected diseases.

作者信息

Lowell Joanna E, Earl Christopher D

机构信息

BIO Ventures for Global Health, Washington, DC, USA.

出版信息

Nat Biotechnol. 2009 Apr;27(4):323-9. doi: 10.1038/nbt0409-323.

DOI:10.1038/nbt0409-323

PMID:19352364

Abstract

摘要

相似文献

Leveraging biotech's drug discovery expertise for neglected diseases.

Nat Biotechnol. 2009 Apr;27(4):323-9. doi: 10.1038/nbt0409-323.

A very firm handshake: biotech's growing negotiating power.

Nat Biotechnol. 2005 Oct;23(10):1221-6. doi: 10.1038/nbt1005-1221.

Biotech's new colossus. Move over, Big Pharma. Amgen boasts better growth.

Fortune. 2002 Apr 15;145(8):144-6, 148, 150.

Biotech's twentieth birthday blues.

Nat Rev Drug Discov. 2003 Mar;2(3):231-3. doi: 10.1038/nrd1036.

Biotechnology partnerships--medicine for an ailing industry?

Nat Biotechnol. 2003 Aug;21(8):847-8. doi: 10.1038/nbt0803-847.

Experts predict bleak post-genomic era for drug R&D.

Nat Med. 2001 Mar;7(3):262. doi: 10.1038/85364.

Advice for partnering with pharma.

Nat Biotechnol. 2004 Nov;22(11):1477-9.

International regional collaborations are paying off.

Nat Biotechnol. 2004 Nov;22(11):1475.

Putting pharmacogenetics into practice.

Nat Biotechnol. 2006 Apr;24(4):403-10. doi: 10.1038/nbt0406-403.

Roche gobbles Smarticles.

Nat Biotechnol. 2015 Oct;33(10):1012. doi: 10.1038/nbt1015-1012a.

引用本文的文献

The genome sequence of Trypanosoma brucei gambiense, causative agent of chronic human african trypanosomiasis.

PLoS Negl Trop Dis. 2010 Apr 13;4(4):e658. doi: 10.1371/journal.pntd.0000658.

本文引用的文献

Mission possible.

Nature. 2007 Sep 13;449(7159):166-9. doi: 10.1038/449166a.

Structural basis for the specific inhibition of protein kinase G, a virulence factor of Mycobacterium tuberculosis.

Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12151-6. doi: 10.1073/pnas.0702842104. Epub 2007 Jul 6.

Evaluation of broad spectrum protein kinase inhibitors to probe the architecture of the malarial cyclin dependent protein kinase Pfmrk.

Bioorg Med Chem Lett. 2007 Sep 1;17(17):4961-6. doi: 10.1016/j.bmcl.2007.06.032. Epub 2007 Jun 12.

The Trypanosoma brucei cAMP phosphodiesterases TbrPDEB1 and TbrPDEB2: flagellar enzymes that are essential for parasite virulence.

FASEB J. 2007 Mar;21(3):720-31. doi: 10.1096/fj.06-6818com. Epub 2006 Dec 13.

Global framework on essential health R&D.

Lancet. 2006 May 13;367(9522):1560-1. doi: 10.1016/S0140-6736(06)68672-8.

Developing drugs for developing countries.

Health Aff (Millwood). 2006 Mar-Apr;25(2):313-24. doi: 10.1377/hlthaff.25.2.313.

Experiments in social responsibility.

Nature. 2006 Jan 19;439(7074):267-8. doi: 10.1038/439267a.

Protein kinases as drug targets in trypanosomes and Leishmania.

Biochim Biophys Acta. 2005 Dec 30;1754(1-2):151-9. doi: 10.1016/j.bbapap.2005.08.018. Epub 2005 Sep 8.

Designing drugs for parasitic diseases of the developing world.

PLoS Med. 2005 Aug;2(8):e210. doi: 10.1371/journal.pmed.0020210. Epub 2005 Aug 30.

PfPDE1, a novel cGMP-specific phosphodiesterase from the human malaria parasite Plasmodium falciparum.

Biochem J. 2005 Nov 15;392(Pt 1):221-9. doi: 10.1042/BJ20050425.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验

相似文献

Leveraging biotech's drug discovery expertise for neglected diseases.

Nat Biotechnol. 2009 Apr;27(4):323-9. doi: 10.1038/nbt0409-323.

A very firm handshake: biotech's growing negotiating power.

Nat Biotechnol. 2005 Oct;23(10):1221-6. doi: 10.1038/nbt1005-1221.

Biotech's new colossus. Move over, Big Pharma. Amgen boasts better growth.

Fortune. 2002 Apr 15;145(8):144-6, 148, 150.

Biotech's twentieth birthday blues.

Nat Rev Drug Discov. 2003 Mar;2(3):231-3. doi: 10.1038/nrd1036.

Biotechnology partnerships--medicine for an ailing industry?

Nat Biotechnol. 2003 Aug;21(8):847-8. doi: 10.1038/nbt0803-847.

Experts predict bleak post-genomic era for drug R&D.

Nat Med. 2001 Mar;7(3):262. doi: 10.1038/85364.

Advice for partnering with pharma.

Nat Biotechnol. 2004 Nov;22(11):1477-9.

International regional collaborations are paying off.

Nat Biotechnol. 2004 Nov;22(11):1475.

Putting pharmacogenetics into practice.

Nat Biotechnol. 2006 Apr;24(4):403-10. doi: 10.1038/nbt0406-403.

Roche gobbles Smarticles.

Nat Biotechnol. 2015 Oct;33(10):1012. doi: 10.1038/nbt1015-1012a.

引用本文的文献

The genome sequence of Trypanosoma brucei gambiense, causative agent of chronic human african trypanosomiasis.

PLoS Negl Trop Dis. 2010 Apr 13;4(4):e658. doi: 10.1371/journal.pntd.0000658.

本文引用的文献

Mission possible.

Nature. 2007 Sep 13;449(7159):166-9. doi: 10.1038/449166a.

Structural basis for the specific inhibition of protein kinase G, a virulence factor of Mycobacterium tuberculosis.

Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12151-6. doi: 10.1073/pnas.0702842104. Epub 2007 Jul 6.

Evaluation of broad spectrum protein kinase inhibitors to probe the architecture of the malarial cyclin dependent protein kinase Pfmrk.

Bioorg Med Chem Lett. 2007 Sep 1;17(17):4961-6. doi: 10.1016/j.bmcl.2007.06.032. Epub 2007 Jun 12.

The Trypanosoma brucei cAMP phosphodiesterases TbrPDEB1 and TbrPDEB2: flagellar enzymes that are essential for parasite virulence.

FASEB J. 2007 Mar;21(3):720-31. doi: 10.1096/fj.06-6818com. Epub 2006 Dec 13.

Global framework on essential health R&D.

Lancet. 2006 May 13;367(9522):1560-1. doi: 10.1016/S0140-6736(06)68672-8.

Developing drugs for developing countries.

Health Aff (Millwood). 2006 Mar-Apr;25(2):313-24. doi: 10.1377/hlthaff.25.2.313.

Experiments in social responsibility.

Nature. 2006 Jan 19;439(7074):267-8. doi: 10.1038/439267a.

Protein kinases as drug targets in trypanosomes and Leishmania.

Biochim Biophys Acta. 2005 Dec 30;1754(1-2):151-9. doi: 10.1016/j.bbapap.2005.08.018. Epub 2005 Sep 8.

Designing drugs for parasitic diseases of the developing world.

PLoS Med. 2005 Aug;2(8):e210. doi: 10.1371/journal.pmed.0020210. Epub 2005 Aug 30.

PfPDE1, a novel cGMP-specific phosphodiesterase from the human malaria parasite Plasmodium falciparum.

Biochem J. 2005 Nov 15;392(Pt 1):221-9. doi: 10.1042/BJ20050425.