Mashima T, Seimiya H, Tsuruo T
Division of Molecular Biotherapy, Cancer Chemotherapy Centre, Japanese Foundation for Cancer Research, 3-10-6 Ariake, Koto-ku, Tokyo 135-8550, Japan.
Br J Cancer. 2009 May 5;100(9):1369-72. doi: 10.1038/sj.bjc.6605007. Epub 2009 Apr 7.
Enhanced lipid biosynthesis is a characteristic feature of cancer. Deregulated lipogenesis plays an important role in tumour cell survival. These observations suggest that enzymes in the lipid synthesis pathway would be rational therapeutic targets for cancer. To this end, we review the enzymes in de novo fatty-acid synthesis and related pathways.
脂质生物合成增强是癌症的一个特征。脂肪生成失调在肿瘤细胞存活中起重要作用。这些观察结果表明，脂质合成途径中的酶将是癌症合理的治疗靶点。为此，我们综述了从头脂肪酸合成及相关途径中的酶。
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