Llistosella E, Codina A, Alvarez R, Pujol R M, de Moragas J M
Department of Dermatology, Hospital de Girona, Spain.
Cutis. 1991 Sep;48(3):205-7.
Four patients with colorectal cancer treated with tegafur (a fluoropyrimidine structurally similar to 5-fluorouracil) noted a macular, spotted hyperpigmentation limited to the palms, soles, nails, and glans penis. Histopathologic examination disclosed epidermal basal hyperpigmentation with a lentiginous pattern. Mucocutaneous lesions resolved spontaneously two months after treatment was discontinued. This peculiar phenomenon seems to represent a previously unreported side effect of this cytotoxic drug.
四名接受替加氟（一种结构与5-氟尿嘧啶相似的氟嘧啶）治疗的结直肠癌患者出现了仅限于手掌、脚底、指甲和阴茎龟头的斑片状、斑点状色素沉着。组织病理学检查显示表皮基底色素沉着呈雀斑样模式。停药两个月后，皮肤黏膜病变自行消退。这种特殊现象似乎代表了这种细胞毒性药物一种此前未报道的副作用。
