Wang G L, Zhu C
Department of Neurosurgery, Changzheng Hospital, Second Military Medical University, Shanghai.
Chin Med J (Engl). 1991 Sep;104(9):764-9.
Using radioimmunoassay (RIA) concentrations of immunoreactive TRH (TRH-ir) in cerebrospinal fluid (CSF) and plasma were determined after acute head injury in 29 patients. The results showed that the concentrations of TRH-ir (pmol/L) in CSF and plasma on the days when injuries were sustained were 29.25 +/- 8.92 pg/ml and 30.29 +/- 8.26 (1 pg/ml = 2.8 pmol/L) in mildly (n = 12), 57.78 +/- 11.72 and 65.27 +/- 8.57 in moderately (n = 9), and 70.09 +/- 7.58 and 85.65 +/- 7.92 in severely (n = 8), head-injured patients. While the concentrations of TRH-ir in CSF and plasma were 25.11 +/- 11.85 and 27.90 +/- 11.39 in the control group (n = 10). Dynamic observations revealed that the contents of TRH-ir in CSF and plasma were gradually recovered to their control levels when improvement of the head-injured patients took place. But they were significantly decreased and became much lower than the control levels in patients with poor prognosis. These results suggest that the assay of TRH-ir in CSF and plasma has clinical significance in reflecting the severity and prognosis of acute head-injured patients.
采用放射免疫分析法（RIA）测定了29例急性颅脑损伤患者脑脊液（CSF）和血浆中免疫反应性促甲状腺激素释放激素（TRH-ir）的浓度。结果显示，轻度颅脑损伤患者（n = 12）受伤当日脑脊液和血浆中TRH-ir的浓度（pmol/L）分别为29.25±8.92 pg/ml和30.29±8.26（1 pg/ml = 2.8 pmol/L）；中度颅脑损伤患者（n = 9）分别为57.78±11.72和65.27±8.57；重度颅脑损伤患者（n = 8）分别为70.09±7.58和85.65±7.92。而对照组（n = 10）脑脊液和血浆中TRH-ir的浓度分别为25.11±11.85和27.90±11.39。动态观察发现，随着颅脑损伤患者病情好转，脑脊液和血浆中TRH-ir的含量逐渐恢复至对照水平。但预后不良的患者其TRH-ir含量显著降低，且远低于对照水平。这些结果提示，检测脑脊液和血浆中的TRH-ir对反映急性颅脑损伤患者的病情严重程度及预后具有临床意义。
