Schabert Vernon F, Bavendam Tamara, Goldberg Erica L, Trocio Jeffrey N, Brubaker Linda
IMS Health, Inc, Health Economics and Outcomes Research, 300 N Washington St, Ste 300, Falls Church, VA 22046, USA.
Am J Manag Care. 2009 Mar;15(4 Suppl):S118-22.
Describe challenges to improving management of overactive bladder (OAB) outcomes and summarize research findings on critical success factors for supporting OAB treatment.
A multidisciplinary team collected primary and secondary data, including an OAB-specific survey; a literature review; and an expert panel discussion.
A US survey of patients who were prescribed antimuscarinics included topics related to OAB, such as reasons for medication discontinuation. The PubMed database was searched for articles published in the past 10 years on OAB treatment and adherence, and additional publications were reviewed related to health behavior change models. An expert panel reviewed findings and provided perspective.
The survey (n = 5392) showed that, among patients discontinuing OAB medications, 45.4% reported unmet treatment expectations as the reason for discontinuation. Literature review findings supported intervention at the beginning of OAB treatment, specific messages to increase treatment adherence, and involving the healthcare stakeholders most trusted by patients. Implications of OAB patient support were drawn from reviews of the Transtheoretical Model, the Health Belief Model, and social learning theory. The expert panel highlighted desirable attributes of OAB patient education delivered in the medical care setting.
Challenges to improving OAB symptom burden and outcomes include underdiagnosis, undertreatment, and patient nonadherence with medications. Patient support of medication adherence may be enhanced by simultaneously supporting the use of nonpharmaceutical lifestyle modifications and behavioral interventions. Healthcare providers acknowledge the need for patient education but lack the time and resources to deliver interventions or monitor patients' progress outside the medical office. Patient support may be achieved through external programs that complement patient-physician interactions.
描述改善膀胱过度活动症(OAB)治疗效果所面临的挑战,并总结支持OAB治疗的关键成功因素的研究结果。
一个多学科团队收集了主要和次要数据,包括一项针对OAB的调查、文献综述以及专家小组讨论。
在美国对开具抗胆碱能药物的患者进行调查,调查主题包括与OAB相关的内容,如停药原因。在PubMed数据库中搜索过去10年发表的关于OAB治疗和依从性的文章,并查阅了与健康行为改变模型相关的其他出版物。一个专家小组对研究结果进行了审查并提供了观点。
调查(n = 5392)显示,在停用OAB药物的患者中,45.4%报告称未满足治疗期望是停药原因。文献综述结果支持在OAB治疗开始时进行干预、提供提高治疗依从性的特定信息以及让患者最信任的医疗利益相关者参与进来。从对跨理论模型、健康信念模型和社会学习理论的综述中得出了OAB患者支持的意义。专家小组强调了在医疗环境中提供OAB患者教育的理想属性。
改善OAB症状负担和治疗效果面临的挑战包括诊断不足、治疗不足以及患者不依从药物治疗。通过同时支持使用非药物生活方式改变和行为干预措施,可能会增强患者对药物依从性的支持。医疗保健提供者承认需要对患者进行教育,但缺乏在医疗办公室之外提供干预措施或监测患者进展的时间和资源。可以通过补充患者与医生互动的外部项目来实现患者支持。