Aslami Hamid, Schultz Marcus J, Juffermans Nicole P
Laboratory of Experimental Intensive Care and Anesthesiology (L.E.I.C.A.), Academic Medical Center, room M0-127, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
Curr Med Chem. 2009;16(10):1295-303. doi: 10.2174/092986709787846631.
A suspended animation-like state has been induced in rodents with the use of hydrogen sulfide, resulting in hypothermia with a concomitant reduction in metabolic rate. Also oxygen demand was reduced, thereby protecting against hypoxia. Several therapeutic applications of induction of a hibernation-like state have been suggested, including ischemia-reperfusion injury. More recently, hydrogen sulfide has been found to be protective in states of exaggerated inflammatory responses, such as acute lung injury. Possible mechanisms of this protective effect may include reduction of metabolism, as well as reduction of inflammation. In this manuscript, the methods of inducing a suspended animation-like state in experimental models using hydrogen sulfide are described. We discuss the effects of hydrogen sulfide-induced hypo-metabolism on hemodynamic, metabolic and inflammatory changes in animal models of various hypoxic and inflammatory diseases. In addition, potential therapeutic possibilities of hydrogen sulfide-induced hibernation are outlined.
使用硫化氢已在啮齿动物中诱导出类似假死的状态，导致体温过低并伴有代谢率降低。同时氧需求也降低，从而预防缺氧。有人提出诱导类似冬眠状态的几种治疗应用，包括缺血再灌注损伤。最近，已发现硫化氢在诸如急性肺损伤等过度炎症反应状态下具有保护作用。这种保护作用的可能机制可能包括代谢降低以及炎症减轻。在本手稿中，描述了在实验模型中使用硫化氢诱导类似假死状态的方法。我们讨论了硫化氢诱导的低代谢对各种缺氧和炎症性疾病动物模型中血流动力学、代谢和炎症变化的影响。此外，还概述了硫化氢诱导冬眠的潜在治疗可能性。
