Blackstone Eric, Morrison Mike, Roth Mark B
Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.
Science. 2005 Apr 22;308(5721):518. doi: 10.1126/science.1108581.
Mammals normally maintain their core body temperature (CBT) despite changes in environmental temperature. Exceptions to this norm include suspended animation-like states such as hibernation, torpor, and estivation. These states are all characterized by marked decreases in metabolic rate, followed by a loss of homeothermic control in which the animal's CBT approaches that of the environment. We report that hydrogen sulfide can induce a suspended animation-like state in a nonhibernating species, the house mouse (Mus musculus). This state is readily reversible and does not appear to harm the animal. This suggests the possibility of inducing suspended animation-like states for medical applications.
哺乳动物通常能在环境温度变化时维持其核心体温（CBT）。这种常态的例外情况包括类似假死的状态，如冬眠、蛰伏和夏眠。这些状态的共同特征是代谢率显著降低，随后失去体温调节能力，动物的核心体温接近环境温度。我们报告称，硫化氢能在非冬眠物种家鼠（小家鼠）中诱导出类似假死的状态。这种状态很容易逆转，且似乎不会对动物造成伤害。这表明了诱导类似假死状态用于医学应用的可能性。
