Intracellular delivery of nanogel-quantum dot hybrid nanoparticles into human periodontal ligament cells.

作者信息

Fukui Tomoe, Kobayashi Hiroaki, Hasegawa Urara, Nagasawa Toshiyuki, Akiyoshi Kazunari, Ishikawa Isao

机构信息

Section of Periodontology, Department of Hard Tissue Engineering, Graduate School, Tokyo Medical and Dental University 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8549, Japan.

出版信息

Drug Metab Lett. 2007 Apr;1(2):131-5. doi: 10.2174/187231207780363570.

DOI:10.2174/187231207780363570

PMID:19356032

Abstract

Nanogels of cholesterol-bearing pullulan modified with amino-groups (CHPNH(2)) were utilized as a career to introduce quantum dots (QDs) into periodontal ligament (PDL) cells. Nanogel-QD effectively labeled PDL cells over 3 weeks. These results indicate that CHPNH(2)nanogels have a potential as a research tool in the studies of intracellular delivery system.

摘要