Sandhu Punam, Andrews Paul A, Baker Maribeth P, Koeplinger Kenneth A, Soli Eric D, Miller Thomas, Baillie Thomas A
Department of Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania 19486, USA.
Drug Metab Lett. 2007 Apr;1(2):153-61. doi: 10.2174/187231207780363642.
The disposition of vorinostat, an anticancer agent, was investigated in rats and dogs. Vorinostat possessed high serum clearance, a short elimination half-life and low oral bioavailability in both species. The renal route played an important role in the elimination of drug-related material and vorinostat was eliminated primarily by metabolic biotransformation.
在大鼠和犬体内研究了抗癌药伏立诺他的处置情况。伏立诺他在这两种动物体内均具有高血清清除率、短消除半衰期和低口服生物利用度。肾脏途径在与药物相关物质的消除中起重要作用，伏立诺他主要通过代谢生物转化被消除。
Zotero 插件