Must Anne, Tasa Gunnar, Lang Aavo, Vasar Eero, Kõks Sulev, Maron Eduard, Väli Marika
Institute of Physiology, Tartu University, Ravila 19, Tartu 50411, Estonia.
Neurosci Lett. 2009 Apr 3;453(2):112-4. doi: 10.1016/j.neulet.2009.02.010. Epub 2009 Feb 10.
Dysfunction of the central serotonergic system has been related to a spectrum of psychiatric disorders, including suicidal behavior. Tryptophan hydroxylase isoform 2 (TPH2) is the rate-limiting enzyme in the biosynthetic pathway of serotonin, being expressed in serotonergic neurons of raphe nuclei. We investigated genetic variation in TPH2 gene in two samples of male subjects: 288 suicide completers and 327 volunteers, in order to reveal any associations between 14 single nucleotide polymorphisms and completed suicide. No associations were revealed neither on allelic nor haplotype level. Our finding does not support the hypothesis of TPH2 being a susceptibility factor for completed suicide in males of Estonian origin.
中枢5-羟色胺能系统功能障碍与一系列精神疾病有关，包括自杀行为。色氨酸羟化酶同工酶2（TPH2）是5-羟色胺生物合成途径中的限速酶，在中缝核的5-羟色胺能神经元中表达。我们在两组男性受试者样本中研究了TPH2基因的遗传变异：288例自杀成功者和327名志愿者，以揭示14个单核苷酸多态性与自杀死亡之间的任何关联。在等位基因水平和单倍型水平上均未发现关联。我们的研究结果不支持TPH2是爱沙尼亚裔男性自杀死亡易感性因素的假说。
