Buggiani G, Troiano M, Rossi R, Lotti T
Dermatology and Physiotherapy Unit, Department of Dermatological Sciences, University of Florence School of Medicine, Via Lorenzo il Magnifico 104, 50129 Florence, Italy.
Photodiagnosis Photodyn Ther. 2008 Jun;5(2):134-8. doi: 10.1016/j.pdpdt.2008.03.001. Epub 2008 May 6.
Photodynamic therapy (PDT) is a treatment technique that permits the clearance of different skin lesions with high success rates in many dermatological diseases. Worldwide recognized uses for PDT in dermatology include non-melanoma skin cancer, actinic keratoses, acne vulgaris, photorejuvenation, and hidradenitis suppurativa. In the European Union, and in the USA, its indication is for the treatment of nonhyperkeratotic actinic keratoses (AKs) of the face and scalp, for basal cell carcinoma and for Bowen's disease. However, due to its intriguing mechanism of action, many dermatologists have begun to look at the use of PDT in photorejuvenation, acne vulgaris and hidradenitis suppurativa. Moreover, clinicians have to learn how to maximize this kind of therapy to treat other dermatologic entities, and many anecdotic reports can already be found in the literature. This paper aims to briefly but critically review these reports to give the dermatologist a useful guide to what could be the future experiences in PDT and how to target their efforts in clinics and research.
光动力疗法（PDT）是一种治疗技术，在许多皮肤病中，它能成功清除不同的皮肤病变。光动力疗法在皮肤科领域得到全球认可的应用包括非黑素瘤皮肤癌、光化性角化病、寻常痤疮、光嫩肤以及化脓性汗腺炎。在欧盟和美国，其适应证为治疗面部和头皮的非角化过度性光化性角化病（AKs）、基底细胞癌和鲍温病。然而，由于其有趣的作用机制，许多皮肤科医生已开始关注光动力疗法在光嫩肤、寻常痤疮和化脓性汗腺炎中的应用。此外，临床医生必须学会如何最大限度地利用这种疗法来治疗其他皮肤疾病，并且在文献中已经可以找到许多轶事报道。本文旨在简要但批判性地回顾这些报道，为皮肤科医生提供一份有用的指南，介绍光动力疗法未来可能的经验以及如何在临床和研究中有的放矢地开展工作。
