Backovic Marija, Jardetzky Theodore S
Department of Virology, Pasteur Institute, 25 rue du Dr. Roux, Paris, France.
Curr Opin Struct Biol. 2009 Apr;19(2):189-96. doi: 10.1016/j.sbi.2009.02.012. Epub 2009 Apr 6.
Accumulating structural studies of viral fusion glycoproteins have revealed unanticipated structural relationships between unrelated virus families and allowed the grouping of these membrane fusogens into three distinct classes. Here we review the newly identified group of class III viral fusion proteins, whose members include fusion proteins from rhabdoviruses, herpesviruses, and baculoviruses. While clearly related in structure, the class III viral fusion proteins exhibit distinct structural features in their architectures as well as in their membrane interacting fusion loops, which are likely related to their virus-specific differences in cellular entry. Further study of the similarities and differences in the class III viral fusion glycoproteins may provide greater insights into protein:membrane interactions that are key to promoting efficient bilayer fusion during virus entry.
对病毒融合糖蛋白的结构研究不断积累，揭示了不相关病毒家族之间意想不到的结构关系，并使这些膜融合蛋白可分为三个不同的类别。在此，我们综述新发现的III类病毒融合蛋白，其成员包括弹状病毒、疱疹病毒和杆状病毒的融合蛋白。虽然III类病毒融合蛋白在结构上明显相关，但它们在结构以及与膜相互作用的融合环方面表现出独特的结构特征，这可能与它们在细胞进入过程中病毒特异性差异有关。对III类病毒融合糖蛋白异同的进一步研究，可能会为蛋白质与膜的相互作用提供更深入的见解，而这种相互作用是病毒进入过程中促进有效双层膜融合的关键。
