Karthikeyan S, Krishnamoorthy M S
Department of Pharmacology and Environmental Toxicology, University of Madras, India.
Drug Chem Toxicol. 1991;14(3):293-303. doi: 10.3109/01480549109002191.
The effect of subacute intraperitoneal administration of Isoniazid (INH) on various lipid parameters was studied in liver and adipose tissue in addition to plasma. In the liver, its effect on various phospholipid fractions was also assessed. The changes in lipid profile reflected INH-induced hepatic steatosis. While pyridoxine alone did not alter any of these lipid parameters, its concurrent administration with INH prevented almost all the INH-induced lipid changes. The enhanced lipid mobilization into liver, and a fall in phosphatidylcholine with a concomitant rise in phosphatidylethanolamine in liver impeding lipoprotein synthesis, might be responsible for the hepatic steatosis. Pyridoxal, a pyridoxine metabolite, might have trapped the primary amine functional group of acetylhydrazine and thus prevented the steatosis.
除血浆外，还研究了亚急性腹腔内注射异烟肼（INH）对肝脏、脂肪组织中各种脂质参数的影响。在肝脏中，还评估了其对各种磷脂组分的影响。脂质谱的变化反映了INH诱导的肝脂肪变性。单独使用吡哆醇不会改变任何这些脂质参数，但与INH同时给药可几乎完全防止INH诱导的脂质变化。脂质向肝脏的动员增强，肝脏中磷脂酰胆碱下降，同时磷脂酰乙醇胺上升，阻碍脂蛋白合成，可能是肝脂肪变性的原因。吡哆醛是吡哆醇的代谢产物，可能捕获了乙酰肼的伯胺官能团，从而预防了脂肪变性。
