Kargar Jahromi Hossein, Pourahmad Morteza, Abedi Hassan Ali, Karimi Mohadeseh, Kargar Jahromi Zahra
Zoonoses Research Center, Jahrom University of Medical Sciences, Jahrom, Iran.
Research Center for Noncommunicable Diseases, Faculty of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran.
J Tradit Complement Med. 2017 Jun 21;8(1):239-243. doi: 10.1016/j.jtcme.2017.06.001. eCollection 2018 Jan.
Isoniazid is a drug for treatment of tuberculosis. One of the main side effects of this drug is hepatotoxicity, which is a major cause of treatment interruption in tuberculosis. This study is about the preventive effect of Salep on this side effect of isoniazid.
This study is an experimental study in which the preventive effect of salep on isoniazid hepatotoxicity is evaluated. In this study 56 rats were randomly placed in 7 eight members groups including: control group, sham, isoniazid and four isoniazid/salep groups. At the end of the study the laboratory criteria and histological features of liver toxicity were compared in different mentioned groups.
Significant lower serum levels of liver enzymes, billirubin, MDA and TOC; and significant higher levels of TAC and total proteins, were revealed in isoniazid/salep group in compare to isoniazid alone group.In addition, histological studies had not showed liver injury in isoniazid/salep group, while there was significant liver injury in isoniazid alone group.
Orchid extract (salep), probably because of its antioxidant properties, prevent the destructive effects of isoniazid on the liver.
异烟肼是一种治疗结核病的药物。该药物的主要副作用之一是肝毒性，这是结核病治疗中断的主要原因。本研究旨在探讨沙雷普对异烟肼这一副作用的预防作用。
本研究为实验性研究，评估沙雷普对异烟肼肝毒性的预防作用。在本研究中，56只大鼠被随机分为7组，每组8只，包括：对照组、假手术组、异烟肼组以及四个异烟肼/沙雷普组。研究结束时，对上述不同组别的肝脏毒性实验室指标和组织学特征进行比较。
与单独使用异烟肼组相比，异烟肼/沙雷普组的血清肝酶、胆红素、丙二醛和总氧化氮水平显著降低；而总抗氧化能力和总蛋白水平显著升高。此外，组织学研究显示异烟肼/沙雷普组未出现肝损伤，而单独使用异烟肼组存在明显肝损伤。
兰花提取物（沙雷普）可能因其抗氧化特性，可预防异烟肼对肝脏的破坏作用。
