中枢神经系统累及慢性炎症性脱髓鞘性多发性神经病：一项电生理和磁共振成像研究。

CNS involvement in chronic inflammatory demyelinating polyneuropathy: an electrophysiological and MRI study.

作者信息

Uncini A, Gallucci M, Lugaresi A, Porrini A M, Onofrj M, Gambi D

机构信息

Institute of Clinical Neurology and Behavioral Sciences, University of Chieti, Italy.

出版信息

Electromyogr Clin Neurophysiol. 1991 Sep;31(6):365-71.

PMID:1935761

Abstract

Eight consecutive patients with chronic inflammatory demyelinating polyneuropathy (CIDP) were investigated by visual evoked potential (VEP), brainstem auditory evoked response (BAER) and magnetic resonance imaging (MRI) to assess central nervous system (CNS) involvement. VEPs were abnormal in 6 patients and BAERs in 2. MRI showed changes suggestive of CNS demyelination in 2 cases. Our findings suggest the existence of a combined central and peripheral demyelinating syndrome and emphasize the possibility of a common pathogenetic mechanism for both.

摘要

对8例连续性慢性炎症性脱髓鞘性多发性神经病（CIDP）患者进行了视觉诱发电位（VEP）、脑干听觉诱发电位（BAER）及磁共振成像（MRI）检查，以评估中枢神经系统（CNS）受累情况。6例患者VEP异常，2例患者BAER异常。2例患者MRI显示有提示CNS脱髓鞘的改变。我们的研究结果提示存在中枢和周围联合脱髓鞘综合征，并强调两者可能有共同的发病机制。