芒果（漆树科）乙醇水叶提取物对大鼠的抗生育活性。
Antifertility activity of aqueous ethanolic leaf extract of Spondias mombin (Anacardiaceae) in rats.
作者信息
Uchendu Chukwuka N, Isek Thomas
机构信息
Department of Veterinary Physiology and Pharmacology, University of Nigeria, Nsukka, Nigeria.
出版信息
Afr Health Sci. 2008 Sep;8(3):163-7.
BACKGROUND
Despite the availability of modern (orthodox) medicine, many developing countries, especially in the rural areas, still rely heavily on traditional healers and medicinal plants to meet their primary health care needs and that of their domestic animals. This has been attributed to easy accessibility and low cost of herbal medicine. In Eastern Nigeria, fresh leaves of Spondias mombin is widely used by the natives to aid delivery and to expel the placenta in small ruminants (sheep and goats), especially during difficult labour.
OBJECTIVE
The present study was designed to evaluate the in vivo effects of leaf extracts of S. mombin on reproductive performance of female rats.
METHODS
Acute toxicity test of the plant extract was carried out in rats of both sexes. The anticonceptive and abortifacient activity of the extract were investigated, including the Fertility Index or embryo score of control and treated animals. The estrogenic activity was determined using ovariectomized rats.
RESULTS
The results revealed a relatively non-toxic plant extract. The extract displayed anticonceptive but not abortifacient activity as judged by the number of pregnant animals at the end of the third trimester of pregnancy. The extract did not exhibit any oestrogenic activity.
CONCLUSION
Aqueous ethanol leaf extract of S. mombin has significant anticonceptive activity attributed to a direct action of the extract on the uterus.
背景
尽管现代（正统）医学已可获取，但许多发展中国家，尤其是农村地区，仍严重依赖传统治疗师和药用植物来满足其自身及家畜的基本医疗需求。这归因于草药易于获取且成本低廉。在尼日利亚东部，当地人广泛使用芒果李的新鲜叶子来辅助分娩并排出小型反刍动物（绵羊和山羊）的胎盘，尤其是在难产时。
目的
本研究旨在评估芒果李叶提取物对雌性大鼠生殖性能的体内作用。
方法
对雌雄大鼠进行了植物提取物的急性毒性试验。研究了提取物的抗生育和堕胎活性，包括对照动物和处理动物的生育指数或胚胎评分。使用去卵巢大鼠测定雌激素活性。
结果
结果显示该植物提取物相对无毒。从妊娠晚期结束时的怀孕动物数量判断，该提取物具有抗生育活性，但无堕胎活性。该提取物未表现出任何雌激素活性。
结论
芒果李水乙醇叶提取物具有显著的抗生育活性，这归因于提取物对子宫的直接作用。
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