酸膜叶海桐茎皮水乙醇提取物对雌性大鼠的抗生育活性。
Antifertility activity of aqueous ethanolic extract of Hymenocardia acida stem bark in female rats.
作者信息
Hyacinth Abu Adakole, Nwocha Uchendu Chukwuka
机构信息
Department of Veterinary Physiology, Pharmacology and Biochemistry, College of Veterinary Medicine, University of Agriculture, P.M.B, 2373, Makurdi, Nigeria.
Department of Veterinary Physiology and Pharmacology, Faculty of Veterinary Medicine, University of Nigeria, Nsukka, Nigeria.
出版信息
Iran J Reprod Med. 2011 Summer;9(3):217-22.
BACKGROUND
Hymenocardia acida is traditionally used in African herbal medicine and has numerous therapeutic benefits. But little is known about its potentially negative effects on pregnant women.
OBJECTIVE
The aim of the present study was to evaluate the antifertility effect of aqueous ethanolic extract of Hymenocardia acida stem bark in female Wistar rats.
MATERIALS AND METHODS
Four groups of rats were administered orally aqueous ethanolic extract of Hymenocardia acida at doses of 100, 200 and 400 mg/kg body weight daily for 19 days. The control group received distilled water. On day 20 of gestation, each rat was laparatomised and number of corpora lutea of pregnancy, number of live fetuses as well as the postcoitum fertility index, weights of the foetuses and placentae were determined.
RESULTS
Oral administration of the extract from days 1 to 19 of gestation showed reduction (p<0.05) in the number of corpora lutea of pregnancy and number of live fetuses. Weights of fetuses of extract treated female rats were also smaller (p<0.05) compared with the control. Anti-implantation activity of the treatment groups were 41.4%, 48.3% and 51.7% for groups II to IV respectively, whereas antifertility activity of the groups was found to be 40%, 60% and 60% in the same order.
CONCLUSION
The results suggest that aqueous ethanolic extract of Hymenocardia acida stem bark could induce negative effects on reproductive functions in female albino rats.
背景
酸膜叶海桐传统上用于非洲草药医学，具有多种治疗功效。但对于其对孕妇潜在的负面影响知之甚少。
目的
本研究旨在评估酸膜叶海桐茎皮水乙醇提取物对雌性Wistar大鼠的抗生育作用。
材料与方法
四组大鼠每天口服酸膜叶海桐水乙醇提取物，剂量分别为100、200和400mg/kg体重，持续19天。对照组给予蒸馏水。在妊娠第20天，对每只大鼠进行剖腹手术，测定妊娠黄体数量、活胎数量以及交配后生育指数、胎儿和胎盘重量。
结果
在妊娠第1天至第19天口服提取物显示，妊娠黄体数量和活胎数量减少（p<0.05）。与对照组相比，接受提取物处理的雌性大鼠所产胎儿的体重也较小（p<0.05）。第二至四组的抗着床活性分别为41.4%、48.3%和51.7%，而这些组的抗生育活性依次为40%、60%和60%。
结论
结果表明，酸膜叶海桐茎皮水乙醇提取物可能对雌性白化大鼠的生殖功能产生负面影响。
Zotero 插件