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腰椎综合征中局部麻醉剂与皮质类固醇硬膜外注射治疗的前瞻性研究

[Epidural injection therapy with local anaesthetics versus cortisone in the lumbar spine syndrome: a prospective study].

作者信息

Teske W, Zirke S, Trippe C, Krämer J, Willburger R E, Schott C, Theodoridis T, Beer A-M, Molsberger A

机构信息

Orthopädische Universitätsklinik, Ruhr-Universität Bochum.

出版信息

Z Orthop Unfall. 2009 Mar-Apr;147(2):199-204. doi: 10.1055/s-0029-1185525. Epub 2009 Apr 8.

Abstract

AIM

The prospective randomised double-blind study analyses follow-up data of the therapeutic effects of cortisone versus local anaesthetics using an injection technique close to the nerve root in chronic lumbar spine syndrome.

METHODS

57 patients were included with an MRI-assured clinical diagnosis. The study was performed over a 6-month period to evaluate long-term effects. The level of disability (ODQ), the quantitative and qualitative sensations of pain were separately determined. The t-test was used for interval and relation variables, the chi (2) test for nominal variables and the Mann-Whitney-U-test for ordinal variables.

RESULTS

Significant differences in favour of cortisone were not found for the measured parameters at any time. An improvement for all parameters was seen in both groups between the time t0 and the definite times t1 and t2.

CONCLUSION

The advantage of a combined injection of local anaesthetics and cortisone versus a injection of local anaesthetics alone in epidural-peridural technique in the inpatient treatment of the chronic lumbar spine root compression syndrome could not be detected.

摘要

目的

这项前瞻性随机双盲研究分析了在慢性腰椎综合征中,使用接近神经根的注射技术,可的松与局部麻醉药治疗效果的随访数据。

方法

纳入57例经MRI确诊的临床病例。研究为期6个月,以评估长期效果。分别测定残疾程度(ODQ)、疼痛的定量和定性感觉。对于区间和关系变量使用t检验,对于名义变量使用卡方检验,对于有序变量使用曼-惠特尼-U检验。

结果

在任何时间点,所测参数均未发现显著有利于可的松的差异。在t0时间与确定的t1和t2时间之间,两组所有参数均有改善。

结论

在住院治疗慢性腰椎神经根压迫综合征的硬膜外-硬膜周技术中,未发现局部麻醉药与可的松联合注射相对于单纯局部麻醉药注射的优势。

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