Iseli Tim A, Yelverton Joshua C, Iseli Claire E, Carroll William R, Magnuson J Scott, Rosenthal Eben L
Division of Otolaryngology, Head and Neck Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.
Laryngoscope. 2009 May;119(5):856-60. doi: 10.1002/lary.20200.
OBJECTIVES/HYPOTHESIS: To evaluate head and neck patients undergoing secondary (delayed) free flap reconstructions.
Retrospective chart review.
Of the 523 free flaps between October 2004 and May 2008, 70 patients underwent 71 secondary free flaps. Outcomes include: hospital stay, complications, flap operative time, enterogastric tube, and tracheostomy requirement. Variables assessed include donor site, indication, prior radiation, and extra-cervical vascular anastomosis.
Radial forearm (40.8%) and fibula free flaps (29.6%) were most commonly used. Mean hospital stay was 7.9 days, follow-up 23.5 months, and operative time 323 minutes. Complications occurred in 39.4% in hospital (early) and 31.4% after discharge (late). Many required further surgery (33.8%), tracheostomy at discharge (26.8%), and prolonged enterogastric tube feeding (31%). In-hospital mortality was 1.4%, total flap failure 1.4%, and partial failure 5.6%. The radial forearm required the least operative time (P = .002), and had least tracheostomies at discharge (P = .040). Osteocutaneous fibula took longest (P = .0001), and had the highest tracheostomy rate (P = .047). Early complications were highest with anterolateral thigh flaps (P = .001). Osteoradionecrosis resulted in higher tracheostomy rates at discharge (P = .0001). Osteocutaneous flaps took 111 minutes longer (P = .001), and required more tracheostomies on discharge (P = .031), but with lower fistula rates (P = .046). Previous irradiation and extra-cervical vessels did not significantly impact outcomes.
Secondary free flaps are technically feasible for head and neck reconstruction with low mortality and flap failure rates. The extra-cervical and external carotid vessels were equally effective. Patients considering semi-elective free flap reconstruction for osteoradionecrosis should be cautioned about complication rates and tracheostomy retention.
目的/假设:评估接受二期(延迟)游离皮瓣重建的头颈患者。
回顾性病历审查。
在2004年10月至2008年5月期间的523例游离皮瓣中,70例患者接受了71例二期游离皮瓣手术。结果包括:住院时间、并发症、皮瓣手术时间、胃肠减压管使用情况及气管切开需求。评估的变量包括供区、适应证、既往放疗情况及颈外血管吻合情况。
最常用的是桡侧前臂皮瓣(40.8%)和腓骨游离皮瓣(29.6%)。平均住院时间为7.9天,随访23.5个月,手术时间323分钟。39.4%的患者在住院期间(早期)出现并发症,31.4%的患者在出院后(晚期)出现并发症。许多患者需要进一步手术(33.8%)、出院时气管切开(26.8%)以及延长胃肠减压管喂养时间(31%)。住院死亡率为1.4%,皮瓣完全坏死率为1.4%,部分坏死率为5.6%。桡侧前臂皮瓣所需手术时间最短(P = 0.002),出院时气管切开率最低(P = 0.040)。腓骨骨皮瓣手术时间最长(P = 0.0001),气管切开率最高(P = 0.047)。股前外侧皮瓣早期并发症发生率最高(P = 0.001)。放射性骨坏死导致出院时气管切开率更高(P = 0.0001)。骨皮瓣手术时间长111分钟(P = 0.001),出院时需要更多气管切开(P = 0.031),但瘘管发生率较低(P = 0.046)。既往放疗和颈外血管情况对结果无显著影响。
二期游离皮瓣对头颈重建在技术上是可行的,死亡率和皮瓣坏死率较低。颈外血管和颈外动脉血管同样有效。对于考虑因放射性骨坏死进行半择期游离皮瓣重建的患者,应告知其并发症发生率和气管切开保留情况。