Trembleau Alain
Equipe Avenir/INSERM Développement et Plasticité des Réseaux Neuronaux, CNRS UMR 7102, Université Pierre et Marie Curie - Paris 6, Boîte 12, 9 quai St Bernard, 75005 Paris, France.
J Soc Biol. 2009;203(1):65-73. doi: 10.1051/jbio/2009012. Epub 2009 Apr 10.
The vertebrate neuron axon has long been considered as devoid of the protein synthesis machinery. During the early nineties however, the cytochemical visualization of identified mRNAs within certain rodent neuron axons challenged this dogma of cellular neurobiology. The aim of this paper is to illustrate, taking mainly the mouse olfactory system as an example, conceptual and methodological approaches developed in particular in my group, that aim at identifying the function of these axonal mRNAs.
长期以来,脊椎动物的神经元轴突一直被认为缺乏蛋白质合成机制。然而,在九十年代初,在某些啮齿动物神经元轴突内对特定mRNA进行的细胞化学可视化挑战了这一细胞神经生物学的教条。本文的目的是以小鼠嗅觉系统为例,主要阐述特别是在我的研究小组中开发的概念和方法,这些方法旨在确定这些轴突mRNA的功能。