Patel M N, Chhasatia M R, Gandhi D S
Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar, Gujarat, India.
Bioorg Med Chem Lett. 2009 May 15;19(10):2870-3. doi: 10.1016/j.bmcl.2009.03.078. Epub 2009 Mar 25.
Six new mixed-ligand complexes of Co(II) with ciprofloxacin (Cip) and neutral bidentate ligands have been synthesized and characterized. Binding and cleavage of DNA with the complex were investigated using spectroscopic method, viscosity measurements and gel electrophoresis techniques. Antibacterial activity has been assayed against two Gram((-ve)) and three Gram((+ve)) microorganisms using the doubling dilution technique.
合成并表征了六种钴（II）与环丙沙星（Cip）及中性双齿配体形成的新型混合配体配合物。采用光谱法、粘度测量和凝胶电泳技术研究了该配合物与DNA的结合及切割情况。使用倍比稀释技术测定了该配合物对两种革兰氏阴性菌和三种革兰氏阳性菌的抗菌活性。
