Abe K, Fujino Y, Demizu A, Takauchi Y, Hoshida T, Kamada K, Mashimo T, Yoshiya I
Department of Anesthesiology, Osaka Police Hospital, Japan.
Eur J Anaesthesiol. 1991 Sep;8(5):359-63.
Prostaglandin E1(PGE1) was administered for deliberate hypotension during general anaesthesia in 27 patients undergoing cerebral-aneurysm clip ligation, and the effect of the drug on local cerebral blood flow was studied. Local cerebral blood flow measurements were made using a thermal-gradient blood flowmeter. Control measurements were made immediately before administration of the drug. Local cerebral blood flow was measured 10, 30, 60 and 120 min after starting the drug infusion and 10, 30 and 60 min after discontinuation. The mean blood pressure was reduced significantly by the administration of PGE1. Urine output was increased after commencement of the drug infusion. Local cerebral blood flow did not change. These results suggest that PGE1 may be an appropriate hypotensive drug for use during cerebral-aneurysm clip ligation, because the cerebral blood flow remains within the normal range and the urine output is increased.
对27例接受脑动脉瘤夹闭术的患者在全身麻醉期间给予前列腺素E1（PGE1）以实施控制性低血压，并研究了该药物对局部脑血流量的影响。使用热梯度血流仪测量局部脑血流量。在给药前立即进行对照测量。在开始输注药物后10、30、60和120分钟以及停药后10、30和60分钟测量局部脑血流量。给予PGE1后平均血压显著降低。开始输注药物后尿量增加。局部脑血流量未发生变化。这些结果表明，PGE1可能是脑动脉瘤夹闭术期间使用的一种合适的降压药物，因为脑血流量保持在正常范围内且尿量增加。
