Woon Fu L, Hedges Dawson W
Brigham Young University, Provo, UT, USA.
J Neuropsychiatry Clin Neurosci. 2009 Winter;21(1):5-12. doi: 10.1176/jnp.2009.21.1.5.
Posttraumatic stress disorder (PTSD) may be associated with structural abnormalities in the amygdala. To better characterize amygdala volume in PTSD, the authors conducted a meta-analysis comparing amygdala volumes in PTSD patients and comparison subjects. Using electronic databases, the authors found nine studies comparing amygdala volumes in adult subjects with PTSD with amygdala volumes in comparison subjects (participants unexposed to trauma and participants exposed to trauma but without PTSD). Results showed no significant differences in amygdala volumes between the groups. Within each group, the right amygdala was significantly larger than the left, indicating an asymmetrically lateralized amygdala volume that is preserved in trauma exposure and in PTSD.
创伤后应激障碍（PTSD）可能与杏仁核的结构异常有关。为了更好地描述PTSD患者的杏仁核体积，作者进行了一项荟萃分析，比较了PTSD患者与对照受试者的杏仁核体积。通过电子数据库，作者发现了9项研究，比较了成年PTSD受试者的杏仁核体积与对照受试者（未暴露于创伤的参与者以及暴露于创伤但无PTSD的参与者）的杏仁核体积。结果显示，两组之间的杏仁核体积无显著差异。在每组中，右侧杏仁核明显大于左侧，表明杏仁核体积的不对称侧化在创伤暴露和PTSD中均得以保留。
