Mamedbeĭli A K, Ragimova N D
Georgian Med News. 2009 Mar(168):75-81.
The aim of the research was to determine clinical and echographic features of central nervous system damage and immunological peculiarities of new born with prenatal infections of different etiology. 132 newborns with various intrauterine infections were included to the actual study. The following risk factors for developing of intrauterine infection with primary affection of CNS in newborns were taken into consideration: maternal age >or=30; chronic extragenital and gynecologic disorders, and complicated obstetric history. The heaviest forms of a cerebral pathology were associated with CMVI, Herpes virus and infections with mixed etiology. The most typical echographic symptoms of cerebral affections in newborns with CMVI were bilateral cysts in the field of caudate-thalamus cuttings and caudate nucleus of thalamus (20%), the others were less frequent: calcifications (10%), cysts with primary localization in parietal and occipital areas (13,3%); at HVI - presence of a hypostasis and swelling of the brain (34,3%), cysts in the field of frontal, temporal both parietal shares (14%) and changes in ventricular system of a brain (20%). The hemodynamic changes of haemorrhagic character (47,1%), and also parenchymatous cysts (11,8%) were more often observed in newborns with infection of chlamidial etiology. The mix intrauterine infections were accompanied with development of heavy hemodynamic infringements (64%) and polymorphic structural changes.
该研究的目的是确定不同病因的产前感染新生儿中枢神经系统损伤的临床和超声特征以及免疫特性。132例患有各种宫内感染的新生儿被纳入实际研究。考虑了以下新生儿宫内感染伴中枢神经系统原发性病变的危险因素：母亲年龄≥30岁；慢性生殖器外和妇科疾病以及复杂的产科病史。最严重的脑部病变形式与巨细胞病毒感染（CMVI）、疱疹病毒感染和混合病因感染有关。CMVI感染新生儿脑部病变最典型的超声症状是尾状核-丘脑切面和丘脑尾状核区域的双侧囊肿（20%），其他症状较少见：钙化（10%）、主要位于顶叶和枕叶区域的囊肿（13.3%）；单纯疱疹病毒感染（HVI）时，表现为脑淤血和肿胀（34.3%）、额叶、颞叶和顶叶区域的囊肿（14%）以及脑室系统改变（20%）。衣原体感染的新生儿更常出现出血性血流动力学改变（47.1%）以及实质囊肿（11.8%）。混合性宫内感染伴有严重血流动力学障碍（64%）和多形性结构改变。
