Dalakishvili S, Didebulidze N, Sumbadze Ts, Akuradze N, Melikadze E
Al. Natishvili Institute of Morphology, Tbilisi, Georgia.
Georgian Med News. 2009 Mar(168):82-4.
The phenomenon of longevity as a kind of model of "physiological" aging has been the main research subject of the Department of Gerontology Institute of Morphology (Georgia) since 1970. The researches were conducted under the Multiplan complex program "Bio-anthropological and social and ethnic investigation of nations and ethnic groups with high index of longevity" in the "long-liver" populations of Georgia. The research aimed at studying the changes in the content of the sex steroids and gonadotrophic hormones in the blood plasma of the healthy men aged from 45 to 90 and more years and residing in Georgia. The control reference group consisted of healthy man, aged from 22 to 35 years. In the blood of patients of all age groups there was observed the fall of the testosterone concentration by 34-55% as compared to the control group and growth of the content of luteinizing hormones by 1-10%. There was not observed falling of the testosterone concentration below the normal limits in any age group (11 nmol/l). Therefore, syndrome of partial progressive insufficiency of the androgens is the reality and requires clear therapeutic treatment attitudes and development of substitutive hormonotherapy.
自1970年以来，长寿现象作为一种“生理性”衰老模型，一直是形态学研究所老年医学部（格鲁吉亚）的主要研究课题。这些研究是在“长寿指数高的民族和族群的生物人类学、社会和种族调查”这一综合计划下，在格鲁吉亚的“长寿者”人群中开展的。研究旨在探究年龄在45岁至90岁及以上、居住在格鲁吉亚的健康男性血浆中性类固醇和促性腺激素含量的变化。对照参考组由年龄在22岁至35岁的健康男性组成。与对照组相比，所有年龄组患者血液中的睾酮浓度下降了34%至55%，促黄体生成素含量增长了1%至10%。在任何年龄组中，均未观察到睾酮浓度降至正常范围以下（11纳摩尔/升）。因此，部分进行性雄激素不足综合征是真实存在的，需要明确的治疗态度并开展替代激素疗法。
