Stratton Michael R, Campbell Peter J, Futreal P Andrew
Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.
Nature. 2009 Apr 9;458(7239):719-24. doi: 10.1038/nature07943.
All cancers arise as a result of changes that have occurred in the DNA sequence of the genomes of cancer cells. Over the past quarter of a century much has been learnt about these mutations and the abnormal genes that operate in human cancers. We are now, however, moving into an era in which it will be possible to obtain the complete DNA sequence of large numbers of cancer genomes. These studies will provide us with a detailed and comprehensive perspective on how individual cancers have developed.
所有癌症都是由癌细胞基因组DNA序列发生的变化引起的。在过去的四分之一个世纪里,我们对这些突变以及在人类癌症中起作用的异常基因已经有了很多了解。然而,我们现在正进入一个能够获取大量癌症基因组完整DNA序列的时代。这些研究将为我们提供关于个体癌症如何发展的详细而全面的视角。