国际癌症基因组计划网络。
International network of cancer genome projects.
出版信息
Nature. 2010 Apr 15;464(7291):993-8. doi: 10.1038/nature08987.
Abstract
The International Cancer Genome Consortium (ICGC) was launched to coordinate large-scale cancer genome studies in tumours from 50 different cancer types and/or subtypes that are of clinical and societal importance across the globe. Systematic studies of more than 25,000 cancer genomes at the genomic, epigenomic and transcriptomic levels will reveal the repertoire of oncogenic mutations, uncover traces of the mutagenic influences, define clinically relevant subtypes for prognosis and therapeutic management, and enable the development of new cancer therapies.
摘要
国际癌症基因组联盟（ICGC）成立的目的是协调全球范围内 50 种不同癌症类型和/或亚型的肿瘤的大规模癌症基因组研究。在基因组、表观基因组和转录组水平上对超过 25000 个癌症基因组进行系统研究，将揭示致癌突变的全部内容，揭示诱变影响的痕迹，为预后和治疗管理定义具有临床意义的亚型，并能够开发新的癌症疗法。
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