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肾移植受者的骨坏死:低钙血症是否起作用?

Osteonecrosis in kidney recipients: has hypocalcaemia a role?

机构信息

Department of Rheumatology and Rehabilitation, Mansoura University, Mansoura, Egypt.

出版信息

Rheumatol Int. 2009 Nov;30(1):75-9. doi: 10.1007/s00296-009-0918-3.

DOI:10.1007/s00296-009-0918-3
PMID:19360409
Abstract

In a previous study, the musculoskeletal affections among kidney recipients (KR) were reported, with 63 KR suffering from joint affections. We sought to determine the prevalence of osteonecrosis (ON) among those KR with joint affections, its distribution among the affected joints, and possible risk predictors. KR were subjected to biochemical, haematological, and hepatitis serology estimations. Radiographic and magnetic resonance imaging were performed. Relevant data were retrieved from Patient Information System. Fourteen KR were suffering from ON, with an incidence of 22.2% in KR with joint affections and 12.0% in the target population of KR. The femoral head was affected in 57.1% and the femoral condyles in 28.6%. Hypocalcaemia was observed in KR with ON. Whether hypocalcaemia is a causative or associative of ON yet remains to be decided in forthcoming studies.

摘要

在之前的一项研究中,报道了肾移植受者(KR)的肌肉骨骼疾病,其中 63 名 KR 患有关节疾病。我们旨在确定患有关节疾病的 KR 中骨坏死(ON)的患病率、受累关节的分布以及可能的风险预测因素。对 KR 进行了生化、血液学和肝炎血清学评估。进行了放射学和磁共振成像检查。从患者信息系统中检索了相关数据。14 名 KR 患有 ON,在患有关节疾病的 KR 中的发病率为 22.2%,在 KR 的目标人群中的发病率为 12.0%。股骨头受累占 57.1%,股骨髁受累占 28.6%。ON 患者中观察到低钙血症。低钙血症是否是 ON 的病因或相关因素仍有待未来的研究来决定。

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Osteonecrosis in kidney recipients: has hypocalcaemia a role?肾移植受者的骨坏死:低钙血症是否起作用?
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Long-lasting severe knee pain in a SLE patient after renal transplantation: what is the reason? A case report and literature review.SLE 患者肾移植后持久严重膝关节痛的原因是什么?病例报告及文献复习。
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2
Avascular osteonecrosis in kidney transplant recipients: Risk factors in a recent cohort study and evaluation of the role of secondary hyperparathyroidism.肾移植受者的缺血性骨坏死:近期队列研究的风险因素及继发性甲状旁腺功能亢进症作用的评估。
PLoS One. 2019 Feb 22;14(2):e0212931. doi: 10.1371/journal.pone.0212931. eCollection 2019.

本文引用的文献

1
Musculoskeletal affections among kidney recipients: prevalence and risk predictors.肾移植受者的肌肉骨骼疾病:患病率及风险预测因素
Rheumatol Int. 2008 Sep;28(11):1085-90. doi: 10.1007/s00296-008-0585-9. Epub 2008 Apr 29.
2
Avascular osteonecrosis after renal transplantation.肾移植后缺血性骨坏死
Transplant Proc. 2007 May;39(4):1036-8. doi: 10.1016/j.transproceed.2007.02.031.
3
Spontaneous resolution of osteonecrosis of the femoral head.股骨头坏死的自发缓解
J Bone Joint Surg Am. 2004 Dec;86(12):2594-9. doi: 10.2106/00004623-200412000-00002.
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Polyostotic osteonecrosis in a patient with celiac disease.
Endocr Pract. 1996 Nov-Dec;2(6):385-8. doi: 10.4158/EP.2.6.385.
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Incidence of hip osteonecrosis among renal transplantation recipients: a prospective study.
Clin Radiol. 2004 May;59(5):431-8. doi: 10.1016/j.crad.2003.11.001.
6
Tacrolimus may be associated with lower osteonecrosis rates after renal transplantation.他克莫司可能与肾移植后较低的骨坏死发生率相关。
Clin Orthop Relat Res. 2003 Oct(415):163-70. doi: 10.1097/01.blo.0000093908.26658.df.
7
Joint pain and arthritis in renal transplant recipients and correlation with cyclosporine therapy.肾移植受者的关节疼痛与关节炎及其与环孢素治疗的相关性。
Rheumatol Int. 2003 Jul;23(4):159-62. doi: 10.1007/s00296-002-0283-y. Epub 2003 Feb 12.
8
Osteonecrosis of the femoral head after solid organ transplantation: a prospective study.实体器官移植后股骨头缺血性坏死:一项前瞻性研究。
J Bone Joint Surg Am. 2002 Dec;84(12):2145-51. doi: 10.2106/00004623-200212000-00004.
9
Symptomatic multifocal osteonecrosis. A multicenter study. Collaborative Osteonecrosis Group.症状性多灶性骨坏死。一项多中心研究。协作性骨坏死研究组。
Clin Orthop Relat Res. 1999 Dec(369):312-26.
10
MRI evaluation of steroid- or alcohol-related osteonecrosis of the femoral condyle.类固醇或酒精相关的股骨髁骨坏死的磁共振成像评估
Acta Orthop Scand. 1998 Dec;69(6):598-602. doi: 10.3109/17453679808999263.