β-榄香烯-99mTc(CO)3 缀合物的放射性合成及生物分布研究
Radioactive synthesis and biodistribution study of beta-elemene-99mTc(CO)3 conjugates.
作者信息
Sun Yanhong, Ren Yunfeng, Zhu Hua, Zhang Yuanqing, Liu Guifeng, Zhang Chunchun, Huang Liliang, Xu Jia, Qi Yujin, Shen Yu-Mei
机构信息
Research Center of Radiopharmaceuticals, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, People's Republic of China.
出版信息
J Biol Inorg Chem. 2009 Aug;14(6):899-904. doi: 10.1007/s00775-009-0502-z. Epub 2009 Apr 10.
Beta-elemene, (5S,7R,10S)-(-)-(1-methyl-1-vinyl-2,4-diisopropenylcyclohexane), is an anticancer agent from traditional Chinese herbal medicine. Three novel (99m)Tc(CO)(3)-beta-elemene conjugates were synthesized successfully, and compared with beta-elemene exhibited improved water solubility. A biodistribution and micro single photon emission computed tomography image study showed there is a visible accumulation in Lewis lung cancer tumors.
β-榄香烯，(5S,7R,10S)-(-)-(1-甲基-1-乙烯基-2,4-二异丙烯基环己烷)，是一种来自传统中草药的抗癌剂。成功合成了三种新型的(99m)Tc(CO)₃-β-榄香烯偶联物，与β-榄香烯相比，其水溶性有所提高。生物分布和微型单光子发射计算机断层扫描图像研究表明，在刘易斯肺癌肿瘤中有明显的聚集。
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