Broggini M, Bottà V, Benvenuti C, Fonio W, Congedo M, Parini J
Department of Medicine, Filippo Del Ponte Hospital, Varese, Italy.
Eur J Drug Metab Pharmacokinet. 1991 Apr-Jun;16(2):137-40. doi: 10.1007/BF03189950.
The pharmacokinetics of rokitamycin tablets were studied in 12 healthy volunteers in a randomized cross-over design. The doses tested were 200 mg, 300 mg, 400 mg and 600 mg, as single oral administration. Rokitamycin was absorbed quickly with Tmax for all doses around 30 min after drug intake. Total AUC and Cmax values were linearly related to the administered dose. The buffer formulation determined a low interindividual variation. The overall findings show a good similarity with the data obtained in Japanese subjects. Tolerability was very good.
