Barluenga José, Rodríguez Félix, Fañanás Francisco J
Instituto Universitario de Química Organometálica Enrique Moles, Unidad Asociada al CSIC, Universidad de Oviedo, Julián Clavería 8, E-33006 Oviedo, Spain.
Chem Asian J. 2009 Jul 6;4(7):1036-48. doi: 10.1002/asia.200900018.
Indoles and quinolines are ubiquitous structural motifs in many natural products and biologically active pharmaceuticals. The pursuit of synthetic efficiency has stimulated the design and development of new synthetic strategies to construct these heterocycles. One of the most effective ways of achieving efficiency is to implement reaction cascades, enabling multiple bond-forming and bond-cleaving events to occur in a single synthetic operation, thus circumventing the waste associated with traditional stepwise synthesis. In general, cascade reactions offer the opportunity to access highly functionalized final products from simple starting materials. For all these reasons, it is not a surprise that most of the recently reported methods for the synthesis of indoles and quinolines are based on the use of cascade reactions. In this Focus Review we discuss some of the most representative and interesting recent reports on the synthesis of indoles and quinolines through cascade reactions.
吲哚和喹啉是许多天然产物和生物活性药物中普遍存在的结构单元。对合成效率的追求推动了构建这些杂环的新合成策略的设计与开发。实现效率的最有效方法之一是实施反应串联，使多个成键和断键事件能在单一合成操作中发生，从而避免与传统逐步合成相关的浪费。一般来说，串联反应提供了从简单起始原料获得高度官能化最终产物的机会。基于所有这些原因，最近报道的大多数吲哚和喹啉合成方法基于串联反应的使用也就不足为奇了。在本重点综述中，我们讨论了一些关于通过串联反应合成吲哚和喹啉的最具代表性和趣味性的近期报道。
