胎儿眼球体积：与孕周及双顶径的关系

Fetal eyeball volume: relationship to gestational age and biparietal diameter.

作者信息

Odeh Marwan, Feldman Yulia, Degani Shimon, Grinin Vitali, Ophir Ella, Bornstein Jacob

机构信息

Department of Obstetrics and Gynecology, Western Galilee Hospital, POB 21, Nahariya 22100, Israel.

出版信息

Prenat Diagn. 2009 Aug;29(8):749-52. doi: 10.1002/pd.2274.

DOI:10.1002/pd.2274

PMID:19360822

Abstract

OBJECTIVE

To measure and determine normal values of the fetal eyeball volume between 14 and 40 weeks of gestation.

METHODS

The volume of the fetal eyeball was measured with three-dimensional ultrasound between 14 and 40 weeks of gestation using the VOCAL software.Only singleton pregnancies without fetal growth restriction, diabetes mellitus, hypertension or major fetal malformation were included.

RESULTS

Over all, 203 women were studied. In 125 both eyeballs were measured while in 78 only one eyeball was measured. The volume of the eyeball correlated strongly with gestational age (right: R = 0.946, P < 0.001, n = 171. left: R = 0.945, P < 0.001, n = 156), and with the biparietal diameter (BPD) (right: R = 0.949, P < 0.001, n = 171. left: R = 0.953, P < 0.001, n = 156). Using regression analysis the best correlation between eyeball volume and the BPD were: square of right eyeball = -0.180 + 0.187 BPD, square of left eyeball = -0.182 + 0.187 BPD.

CONCLUSIONS

The volume of the eyeball has strong positive correlations with gestational age and BPD. Our data may be helpful in fetuses suspected of having eye anomalies.

摘要

目的

测量并确定妊娠14至40周胎儿眼球体积的正常值。

方法

在妊娠14至40周期间，使用VOCAL软件通过三维超声测量胎儿眼球体积。仅纳入无胎儿生长受限、糖尿病、高血压或重大胎儿畸形的单胎妊娠。

结果

总体上，对203名女性进行了研究。其中125名测量了双眼球，78名仅测量了单眼球。眼球体积与孕周密切相关（右侧：R = 0.946，P < 0.001，n = 171；左侧：R = 0.945，P < 0.001，n = 156），与双顶径（BPD）也密切相关（右侧：R = 0.949，P < 0.001，n = 171；左侧：R = 0.953，P < 0.001，n = 156）。通过回归分析，眼球体积与BPD之间的最佳相关性为：右侧眼球体积 = -0.180 + 0.187×BPD，左侧眼球体积 = -0.182 + 0.187×BPD。