Thepen T, McMenamin C, Oliver J, Kraal G, Holt P G
Department of Histology, Vrije Universiteit, Amsterdam, The Netherlands.
Eur J Immunol. 1991 Nov;21(11):2845-50. doi: 10.1002/eji.1830211128.
A single intratracheal instillation of liposomes containing dichloro methylene diphosphonate into rats eliminated greater than 80% of the alveolar macrophage (AM phi) population, and the population was not significantly renewed during the ensuing week. AM phi depletion markedly increased local antibody production in the lung wall in pre-primed animals exposed to antigen aerosols. However, AM phi depletion did not affect the normal development of protective tolerance (particularly in the IgE antibody class) to inhaled antigen in immunologically naive rats. These results are discussed in relation to regional control of immune responses in the upper vs. the lower respiratory tract.
向大鼠气管内单次注入含二氯亚甲基二膦酸盐的脂质体，可清除超过80%的肺泡巨噬细胞（AM phi）群体，且在随后一周内该群体没有明显更新。在预先致敏并暴露于抗原气雾剂的动物中，AM phi耗竭显著增加了肺壁局部抗体的产生。然而，AM phi耗竭并不影响免疫未成熟大鼠对吸入抗原的保护性耐受性（尤其是IgE抗体类别）的正常发育。结合上呼吸道与下呼吸道免疫反应的区域控制对这些结果进行了讨论。
