印度南部周期性马来布鲁线虫感染中微丝蚴血症的动态变化及其与疾病发展的关系。
The dynamics of microfilaraemia and its relation with development of disease in periodic Brugia malayi infection in south India.
作者信息
Sabesan S, Krishnamoorthy K, Panicker K N, Vanamail P
机构信息
Vector Control Research Centre (Indian Council of Medical Research), Pondicherry.
出版信息
Epidemiol Infect. 1991 Oct;107(2):453-63. doi: 10.1017/s0950268800049104.
Rates of acquisition and loss of Brugia malayi microfilaraemia were estimated using the parasitological data of a cohort of population in Shertallai, South India. The rate of acquisition of microfilaraemia was found to be dependent on age but not gender. The decline in the rate of acquisition of microfilaraemia in adults above 35 years could be due to the development of acquired immunity. The mean reproductive lifespan for the periodic Brugia malayi adult female worm was estimated to be 3.4 years and it was independent of host age and gender. The age-specific estimated proportion of population at risk (microfilaria carriers who lost their microfilaria in course of time) of developing lymphoedema approximately mirrored the observed age specific prevalence of lymphoedema in the study population. On an average, 99% of population at risk developed disease in different endemic areas is compared and its epidemiological significance is discussed.
利用印度南部舍尔塔莱一组人群的寄生虫学数据，估算了马来布鲁线虫微丝蚴血症的获得率和消失率。发现微丝蚴血症的获得率取决于年龄而非性别。35岁以上成年人微丝蚴血症获得率的下降可能是由于获得性免疫的发展。周期性马来布鲁线虫成年雌虫的平均生殖寿命估计为3.4年，且与宿主年龄和性别无关。特定年龄组发生淋巴水肿的危险人群（随时间推移失去微丝蚴的微丝蚴携带者）的估计比例大致反映了研究人群中观察到的淋巴水肿的特定年龄患病率。比较了不同流行地区平均99%的危险人群发病情况，并讨论了其流行病学意义。
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