Muñoz-Moreno José A, Blanch Andreu Jordi
Fundació Lluita contra la SIDA, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Barcelona, España.
Med Clin (Barc). 2009 May 30;132(20):787-91. doi: 10.1016/j.medcli.2008.12.025. Epub 2009 Apr 9.
Disruption of neurocognitive functioning is one of most frequent complications in patients with HIV infection nowadays. The Highly Active Antiretroviral Therapy (HAART) has demonstrated an improvement associated with its use, although there are different works that show this improvement is achieved in a low proportion of individuals who initiate therapy. The most known characterization of neurocognitive dysfunction is the HIV-associated Dementia (HAD), yet there may also exist the asymptomatic neurocognitive impairment (ANI) or the Minor Cognitive-Motor Disorder (MCMD). This review describes the disorders related to HIV infection, and comments on possible interventions focused on the protection of neurocognitive functioning in HIV-infected people.
神经认知功能障碍是当今HIV感染患者最常见的并发症之一。高效抗逆转录病毒疗法(HAART)已显示出使用该疗法带来的改善,尽管有不同研究表明,开始治疗的个体中只有一小部分能实现这种改善。神经认知功能障碍最广为人知的特征是与HIV相关的痴呆(HAD),但也可能存在无症状神经认知损害(ANI)或轻度认知运动障碍(MCMD)。本综述描述了与HIV感染相关的疾病,并对旨在保护HIV感染者神经认知功能的可能干预措施进行了评论。