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Quaternary ammonium N,N-dichloroamines as topical, antimicrobial agents.

作者信息

Francavilla Charles, Low Eddy, Nair Satheesh, Kim Bum, Shiau Timothy P, Debabov Dmitri, Celeri Chris, Alvarez Nichole, Houchin Ashley, Xu Ping, Najafi Ron, Jain Rakesh

机构信息

NovaBay Pharmaceuticals Inc., Emeryville, CA 94608, United States.

出版信息

Bioorg Med Chem Lett. 2009 May 15;19(10):2731-4. doi: 10.1016/j.bmcl.2009.03.120. Epub 2009 Mar 28.

DOI:10.1016/j.bmcl.2009.03.120
PMID:19362467
Abstract

A series of backbone modified and sulfonic acid replacement analogs of our topical, clinical candidate (iii) were synthesized. Their antimicrobial activities and aqueous stabilities at pH 4 and pH 7 were determined, and has led us to identify quaternary ammonium N,N-dichloroamines as a new class of topical antimicrobial agents.

摘要

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