氯尼达明对艾氏腹水癌细胞膜电特性的影响。

Effects of lonidamine on the membrane electrical properties of Ehrlich ascites tumor cells.

作者信息

Santini M T, Cametti C, Indovina P L, Malorni W, Benassi M, Gentile F P, Castiglione S, Floridi A

机构信息

Laboratorio di Ultrastrutture, Istituto Superiore di Sanità, Roma, Italy.

出版信息

FEBS Lett. 1991 Oct 21;291(2):169-72. doi: 10.1016/0014-5793(91)81275-d.

DOI:10.1016/0014-5793(91)81275-d

PMID:1936258

Abstract

The effects of lonidamine on membrane electrical properties of Ehrlich ascites tumor cells are investigated. Using a dielectric relaxation technique based on the Maxwell-Wagner effect and elaborated by a 'single-shell' fitting procedure, the data indicate that both membrane conductivity and membrane permittivity increase after treatment of these cells with lonidamine while the conductivity of the cytosol remains unchanged. Changes in membrane proteins and/or lipids are suggested which lead to altered membrane structure and/or function.

摘要

研究了氯尼达明对艾氏腹水癌细胞膜电特性的影响。使用基于麦克斯韦-瓦格纳效应并通过“单壳”拟合程序完善的介电弛豫技术，数据表明，用氯尼达明处理这些细胞后，膜电导率和膜电容率均增加，而细胞质溶胶的电导率保持不变。提示膜蛋白和/或脂质发生变化，导致膜结构和/或功能改变。