Hsieh Yu-Chi, Chir Jiun-Ly, Zou Wei, Wu Hsiu-Han, Wu An-Tai
Department of Chemistry, National Changhua University of Education, Changhua 50058, Taiwan.
Carbohydr Res. 2009 May 26;344(8):1020-3. doi: 10.1016/j.carres.2009.03.008. Epub 2009 Mar 12.
A short and highly efficient route to the alpha-anomer of a furanoid sugar-aza-crown ether was developed by a one-pot reductive amination of an alpha-anomer C-ribosyl azido aldehyde. In addition, the beta-anomer furanoid sugar-aza-crown ether was synthesized from a linear disaccharide precursor via amidation and then followed by microwave-assisted amide reduction.
通过α-异头物C-核糖基叠氮醛的一锅法还原胺化反应,开发了一种制备呋喃型糖氮杂冠醚α-异头物的简短且高效的路线。此外,β-异头物呋喃型糖氮杂冠醚是由线性二糖前体通过酰胺化反应合成,然后进行微波辅助的酰胺还原反应得到的。